Treatment of mycetoma depends on the causative organism and since many organisms, both actinomycetes (actinomycetoma) and fungi (eumycetoma), are capable of producing mycetoma, an accurate diagnosis is crucial. Currently, multiple diagnostic tools are used to determine the extent of infections and to identify the causative agents of mycetoma. These include various imaging, cytological, histopat...

Medical treatment of mycetoma depends on its fungal or bacterial etiology. Clinically, these entities share similar features that can confuse diagnosis, causing a lack of therapeutic response due to inappropriate treatment. This review evaluates the response to available antimicrobial agents in actinomycetoma and the current status of antifungal drugs for treatment of eumycetoma.

A Streptomyces albus forearm actinomycetoma that could not be identified by culture was properly identified at the species level by study of an internal fragment of the heat shock protein gene, comparative sequence analysis of 16S ribosomal DNA (rDNA), and the hypervariable gamma-region of the 16S rDNA.

Nocardial brain abscesses remain a clinical challenge. We successfully treated a patient with nocardial brain abscess, mycetoma, pneumonia, and glomerulonephritis. Nocardial soft tissue involvement, mycetoma, is well known. However, the fact that actinomycetoma can metastasize may not be as well appreciated. The association between nocardiosis and glomerulonephritis should be better clarified.

In the current era of modern medicine, neglected tropical disorders though rare, still remain a cause significant morbidity in sufferers. Actinomycetoma is one such disease commonly seen rural population countries. Due to presence other infectious diseases with similar presentation and low yield on cultures, there may be delay correct diagnosis treatment resource poor settings. We present 35 ye...

TO THE EDITOR: Streptomyces spp. are aerobic, gram-positive bacteria of the order Actinomycetales, known for their ability to produce antimicrobial molecules such as streptomycin. Streptomyces spp., usually saprophytic to humans, can cause local cutaneous fistulized nodules known as actinomycetoma or mycetoma. Severe invasive infections have seldom been reported, but most cases reported have oc...