緒 言 1916年Smithが マウスにおい て下垂体剔出時, その甲状腺が萎縮する事実 より下垂体には甲状腺 刺激作用のあること を推論 し,1929年 にはLoeb らがその作用物質,即 ち甲状腺刺激ホルモン(T sx)の 抽出に成功するに及び下垂体 と甲状腺の 有機的 な関連性が注目されるに至つた.更 にこの 後Aronら が下垂体のTSH分 泌 は 循環血中の甲 状腺ホルモン(以 下 「甲ホ」 と略)量 に よって調 節され るこ と,即 ち両者間にfeedback relation が存す ることを認めて以来,こ れが甲状腺機能調 節機構の主軸 をなすと考 えられる様 になつた. 各 種 甲状 腺 疾 宙、々 者 に お け るBMR,PBI, 或 い は1311摂 取 率 等 に よ る 機 能 検 査 は 日常routlne に 行 なわ れ て い る が,一 歩 進...

PHARMAC aims to ensure fair allocation of funding across competing new medicines, and must ensure appropriate targeting of medicines to get best value for money. For this reason, our processes for assessing new pharmaceutical funding applications are necessarily diligent. PHARMAC’s process involves both expert clinical review, negotiation with suppliers, consultation with the health sector, and...

Effective treatment decisions sometimes require substantial risk of short-term harm, which can be shown after-the-fact to have been preventable, thereby carrying some liability risk. To err on the side of short-term comfort or safety, however, may greatly increase the overall and long-term risks. For instance, to intrusively restrain a borderline patient from threatened acting out, may (1) fuel...

Process for the conversion of cyclic amines into lactams" (2012).

Six new fluorinated thiosemicarbazones R‑C(R')=N-NH-C(S)NH(2) (R = 2,4-C(6)H(3)F(2), R' = H (1); R = 2,5-C(6)H(3)F(2), R' = H (2); R = 2,6-C(6)H(3)F(2), R' = H (3); R = 3,4-C(6)H(3)F(2), R' = H (4); R = 3,5-C(6)H(3)F(2), R' = H (5) and R = 4-C(6)H(4)F, R' = C(6)H(5), (6)) have been prepared. The molecular structures of compounds 1 to 6 have been determined.

Arabidopsis encodes four DICER-like (DCL) proteins. DCL1 produces miRNAs, DCL2 produces some virus-derived siRNAs, and DCL3 produces endogenous RDR2-dependent siRNAs, but the role of DCL4 is unknown. We show that DCL4 is the primary processor of endogenous RDR6-dependent trans-acting siRNAs (tasiRNAs). Molecular and phenotypic analyses of all dcl double mutants also revealed partially compensat...

Sports are spontaneous generators of stories. Through skill and chance, the script of each game is dynamically written in real time by players acting out possible trajectories allowed by a sport's rules. By properly characterizing a given sport's ecology of "game stories," we are able to capture the sport's capacity for unfolding interesting narratives, in part by contrasting them with random w...

Etiology and Therapy of Overt Homosexuality Lawrence C. Kolb, M.D. and Adelaide M. Johnson, M.D. Although the origin of latent homosexuality has been discussed frequently in psychoanalytic literature, there has been no definition of those factors that lead to the eruption of overt homosexuality. Many patients have strong latent homosexual impulses, but do not act out these impulses, just as man...

artemisia annua is still the only commercial source of artemisinin. to date, a number of biochemical and molecular studies about artemisinin’s biosynthetic pathway have been carried out. in metabolic engineering approach, isolation and characterization of promoters leads to an understanding of which cis-acting elements are responsible for the regulation of gene expression. dbr2 is a key enzyme ...

background hepatitis b virus (hbv) is a major cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (hcc). hb vaccination is an essential step in the prevention of the disease and its consequent complications. objectives immune status of medical personnel in teaching hospitals of khuzestan is not well known. since these personnel are usually at risk of needle stick and other...