Melanoma cells have been shown to undergo fast amoeboid (leader bleb-based) migration, requiring a single large bleb for migration. In leader blebs, is rapid flow of cortical actin that drives the cell forward. Using RNAi, we find co-depleting cofilin-1 and depolymerizing factor (ADF) led increase in actin, suggesting both proteins regulate actin. Furthermore, severing factors can promote contr...

Introduction The aim was to determine the mitochondrial content, oxidative and nitrosative status in placentas from pregnant women who delivery newborns with alteration of intrauterine growth. Material methods Placentas were selected because classified as small for gestational age (SGA, lowest 10th percentile; n = 9), appropriate (AGA; 9) large (LGA, tallest 90th 9). In placenta tissue status, ...

Waves and dynamic patterns in chemical and physical systems have long interested experimentalists and theoreticians alike. Here we investigate a recent example within the context of cell biology, where waves of actin (a major component of the cytoskeleton) and its regulators (nucleation promoting factors, NPFs) are observed experimentally. We describe and analyze a minimal reaction diffusion mo...

background: in spite of sufficient knowledge about phenotypic variation of trichomonas vaginalis , its genetic characteristics are poorly understood. we carried out a molecular epidemiology study in which in vitro metronidazole susceptibility of t. vaginalis isolates was considered. methods : this study was conducted on 862 women admitted to gynecology clinics in hamadan, west of iran, during 2...

Nakano first discovered the “Mitochondrial cells” (Mito Cells), which can survive for long term despite lacking a nucleus. However, there was no clear evidence to indicate whether MitoCells were alive. To resolve this question, we constructed GFP-actin induced Mito Cell (GFP-actin Cell). Herein, report molecular analysis of both and MitoCells. Our results suggest that have minimum amounts prote...