The effects of acridine derivatives (proflavine and 2,7-dialkyl derivatives, diacridines and triacridines, 9-aminoacridine carboxamides, and 9-anilinoacridine, amsacrine and its congeners) on overall RNA synthesis in vitro, on synthesis of initiating oligonucleotides and the binding of the enzyme to DNA were studied. The primary mechanism of action is related to inhibition of the enzyme binding...

Plasmids are extrachromosomal pieces of double-stranded circular DNA which have the capability to replicate independently of the.Growth dynamics of multiple component communities of bacteria. Thus curing by acridines normally involves loss of the whole plasmid.Plasmids are extrachromasomally replicating molecules of DNA present in bacteria.Plasmid curing is a process of completely removing plas...

R E C E N T studies have distinguished two types of reversible mutations with respect to the type of change in the DNA molecule, in viruses and probably also in higher organisms (BRENNER, BARNETT, CRICK, and ORGEL 1961; MAGNI, personal communication). One type, involving substitution of one base for another and including transitions and possibly transversions, will be referred to here as “subst...

Chloroquine intercalates into DNA and protects cells against topoisomerase II (topo II) poisons such as etoposide by hindering the DNA cleavage reaction of this target enzyme. Chloroquine, in contrast to etoposide, is a weak base and therefore barely enters the cell when the extracellular fluid is acidic, as is the case in most solid tumors. Such a pH-dependent drug interaction could be useful ...