Schimke immuno-osseous dysplasia is a rare autosomal recessive multisystem disorder characterized by steroid-resistant nephrotic syndrome, immunodeficiency, and spondyloepiphy-seal dysplasia. Mutations in SWI/SNF2 related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 (SMARCAL1) gene are responsible for the disease. The present report describes, for the f...

Acquired immune deficiency syndrome (AIDS) is an infectious disease that is caused by the human immuno deficiency virus (HIV). The virus affects and destroys the immune system and causes infected people to become more prone to opportunistic infections (Lindsay 2001:S4). Sub Saharan Africa (SSA) is the worst affected area in the world, with 64% of all people with HIV living in SSA (Joint United ...

This review describes the adjuvanticity of novel diterpenoids (synthetic phytol derivatives) compared to some commercially available adjuvants. The efficacy of the phytol-derived immunostimulants was evaluated in terms of their ability to activate innate immunity, amplify various antigen-specific immune responses, and engender immunological memory with no discernible adverse effects in both com...

Abstract Background Rezafungin (RZF) once weekly (QWk) is a next-generation echinocandin in development for treatment of candidaemia and invasive candidiasis (IC) prevention fungal disease caused by Candida, Aspergillus, Pneumocystis spp. BMT. Objectives The Phase 3 ReSTORE trial (NCT03667690) demonstrated RZF QWk noninferiority to caspofungin (CAS) QD. This sub-analysis evaluated efficacy safe...

T he idiopathic inflammatory myopathies (IIMs) are an important heterogenous group of potentially treatable acquired disorders. On the basis of clinical, histological and immuno-pathogenic features, three distinct subsets are recognised: dermatomyositis (DM), polymyositis (PM) and sporadic inclusion-body myositis (IBM). An accurate diagnosis is important, given the potential toxicity associated...

Recent evidence indicates that we need to change how we think about the etiology and pathogenesis of periodontal disease. Although bacteria are a necessary factor in the equation, the reaction of the host's immuno-inflammatory system is responsible for most of the destruction found in periodontal disease. Thus, it makes sense that a number of environmental and acquired factors may modify a pati...

Candida are true ‘opportunistic pathogens’ and only instigate oral infection when there is an underlying predisposing condition in the host. Oropharyngeal candidiasis is a common occurrence in the course of human immunodeficiency virus (HIV) disease progression. The majority of infections are due to Candida albicans although other species such as Candida glabrata, Candida tropicalis, Candida kr...

BACKGROUND Cases of cytomegalovirus colitis are exceptionally reported in immuno-competent infant. The pathogenesis is uncertain but breast-feeding is considered as a main source of postnatal infection. CASE PRESENTATION Here we report a full-term, formula-fed infant who developed a severe cytomegalovirus anaemia and colitis when aged 2 months. CONCLUSION Even if the molecular identity betw...

Acquired neuromyotonia (Isaac's syndrome) is considered to be an autoimmune disease, and the pathomechanism of nerve hyperexcitability in this syndrome is correlated with anti-voltage-gated K(+) channel (VGKC) antibodies. The patch-clamp technique was used to investigate the effects of immunoglobulins from acquired neuromyotonia patients on VGKCs and voltage-gated Na(+) channels in a human neur...

abstract: potato virus y a type species of the genus potyvirus infects several crops in the family solanaceae. pvy isolated from field infected peppers was identified on the basis of host reaction, serological and molecular characterization. the result of elisa, immunoblot electrophoresis and immuno capture reverse transcription polymerase chain reaction   (ic-rt-pcr) indicated that pepper isol...