Introduction Renal tubular acidosis (RTA) is a non-uremic defects of urinary acidification. It is characterized by a normal anion gap hyperchloremic  metabolic acidosis; plasma potassium may be normal, low or high-depending on the type of RTA. These syndromes differ from uremic acidosis which is associated with a high anion gap, decreased glomerular filtration with enhanced proton secretion b...

Recently, we showed that both acute metabolic acidosis and respiratory acidosis stimulate parathyroid hormone (PTH) secretion in the dog. To evaluate the specific effect of acidosis, ionized calcium (iCa) was clamped at a normal value. Because iCa values normally increase during acute acidosis, we now have studied the PTH response to acute metabolic and respiratory acidosis in dogs in which the...

background: the aim of this study was to evaluate the efficacy of arterial blood gases (abgs) in determining the type of intoxication. methods: medical charts of all patients who had referred to the toxicology ward of baharloo hospital between january 2009 and december 2009 were evaluated. after excluding the patients with multi-drug toxicity, data, including age, sex, type of intoxication (the...

We studied the individual and combined effects of extracellular acidosis and increases in extracellular potassium on action potential characteristics and conduction in order to gain a better understanding of the effects of acute ischemia. At each level of potassium between 2.7 and 17 mm, acidosis induced by increasing Pco2 (respiratory acidosis) and by decreasing HCO3- (metabolic acidosis) decr...

Background: The aim of this study was to evaluate the efficacy of arterial blood gases (ABGs) in determining the type of intoxication. Methods: Medical charts of all patients who had referred to the toxicology ward of Baharloo Hospital between January 2009 and December 2009 were evaluated. After excluding the patients with multi-drug toxicity, data, including age, sex, type of intoxication ...

For induction of ruminal acidosis, 10 clinically healthy three years old non pregnant female sheep were selected. Prior to the infusion of sucrose (0 hour), rumen and blood samples were obtained in order to determine baseline rumen and blood pH, respectively. Electrocardiogram (ECG) was also recorded. Acute ruminal acidosis was induced experimentally with sucrose at a dose of 18g kg-1 body weig...

Metabolic acidosis secondary to lactic acidosis may occur in acute, severe asthma and its presence suggests that respiratory muscle fatigue and tissue hypoxia play a major part in the pathogenesis. Non-anion gap metabolic acidosis (NAG acidosis) has also been reported in acute asthma but its impact on the clinical outcome has not been evaluated. The objective of this study was to evaluate the p...

Background: Metabolic acidosis is a fatal finding in trauma patients that complicates the process of resuscitation. Case: The case was a 37-year-old man with open fracture in both legs and fracture in second lumbar vertebral (L2). The serial arterial blood gas (ABG) test results showed a pH value of 6.7 indicating a very severe and special case of metabolic acidosis. The rate of mortality f...

The effects of chronic metabolic acidosis, alkalosis and alloxan-induced ketoacidosis on G6PD activity of rat kidney, liver and erythrocytes were studied. Metabolic acidosis significantly increased the activity of kidney enzyme (55%) but decreased the liver (43%) and erythrocyte (38%) enzyme activities. Alkalosis did not make a significant change in the kidney or liver enzyme activity but ...