The basiphil cell granules of the human anterior pituitary react positively with Gram's stain, but no specific differentiation of these granules occurs when the iodine treatment is omitted. The granules of the acidophil cells are Gram-negative. Various workers have suggested a connexion between the Gram reaction of various micro-organisms and the presence of ribonucleoprotein, and the pituitary...

The aim of this study is to address the outcomes of endoscopic resection compared with surgery in the treatment of ampullary adenomas. A systematic review and meta-analysis were performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. For this purpose, the Medline, Embase, Cochrane, Literatura Latino-Americana e do Caribe em Ciências da...

Schrire (1937) found that patients with an acidophil tumour of the pituitary excreted creatine in the urine, and this was later confirmed (Cumings, 1944). It was also shown in the latter paper that the fasting blood creatine was raised above the normal in acromegaly, and the results of a creatine tolerance test were given in five cases of pituitary disorders. The cause of the creatinaemia and c...

A 41-year-old male presented with progressive visual defects, acromegaly and hyperthyroidism. After clinical evaluation a giant GH/TSH-secreting pituitary adenoma was diagnosed. Administration of the somatostatin analog octreotide at doses of 150 microg s.c. per day inhibited the secretion of both GH and TSH. A three-week treatment with octreotide prior to surgery led to slight visual improveme...

Bi, RONALD A. WELSH S INCE originally described in 1890 by \Villiam Russell,’ there has been a gradual accumulation of knowledge concerning Russell body formation by the plasma cell, and yet the exact meaning of these bodies is still not cxplained. Russell bodies can he found in the bone marrow of patients with plasmacytosis due to any cause and are seen often in large numbers within areas of c...

We compared the immunoprofile of pituitary adenomas from Romania and Moldova. One hundred and eighty cases coming from Romania (94 cases, group 1) and Moldova (86 cases, group 2) were assessed by immunohistochemistry regarding all six basic hormones expressed in pituitary adenomas. Specific differences and similarities were found and stated for both groups. In group 1, 70% of cases were pituita...