it  is  well  known  that  desensitization  treatment  with  aspirin  can  significantly  improve symptoms and quality of life in patient with aspirin-exacerbated respiratory disease. however, its mechanism has not been clearly understood yet. in this case report, 41-year-old male patient was referred to our allergy and immunology department with complaints of chronic rhinosinusitis including p...

BACKGROUND Salix aegyptiaca is known for its medicinal properties mainly due to the presence of salicylate compounds. However, it also contains other beneficial phytochemicals such as gallic acid, quercetin, rutin and vanillin. The aim of the study was to examine the redox potential, antioxidant and anti-inflammatory activity of these phytochemicals along with acetylsalicylic acid. METHODS Th...

Platelet aggregation and bleeding time was measured in 43 cerebrovascular patients participating in a controlled double-blind study of low-dose acetylsalicylic acid. In 19 patients with satisfactory inhibition of the platelet aggregation obtained by 50 to 70 mg acetylsalicylic acid per day the bleeding time averaged 11.2 minutes in contrast to 7.0 minutes in the placebo group, p less than 0.001...

The present study was undertaken to determine the effect of acetylsalicylic acid acid on the in vitro N-acetyltransferase (NAT) enzyme activity and in vivo acetylation of 2-aminofluorene in laboratory rats. In the in vitro experiments, cytosols of blood, bladder, colon and liver cells, with or without acetylsalicylic acid co-treatment, showed different percentages of 2-aminofluorene acetylation...

Background—A familial defect in intestinal barrier function has been found in Crohn’s disease. Aim—To investigate possible genetic and environmental influences on this barrier defect by studying intestinal permeability in both relatives and spouses of patients with Crohn’s disease. Subjects—The study included 39 patients with Crohn’s disease, 34 healthy first degree relatives, and 22 spouses. T...

OBJECTIVE To investigate the influence of a regular oral use of acetylsalicylic acid in the prevalence of actinic keratosis. METHODS A case-control study with dermatologic outpatients above 50 years of age assessed between 2009 and 2011. Cases were defined as those who had been under regular use of oral acetylsalicylic acid for more than six consecutive months. The assessment focused on: age,...

BACKGROUND A familial defect in intestinal barrier function has been found in Crohn's disease. AIM To investigate possible genetic and environmental influences on this barrier defect by studying intestinal permeability in both relatives and spouses of patients with Crohn's disease. SUBJECTS The study included 39 patients with Crohn's disease, 34 healthy first degree relatives, and 22 spouse...