STUDY OBJECTIVE Treatment with a shortened duration of oral N-acetylcysteine (20 to 48 hours) after acute acetaminophen poisoning is effective in the prevention of subsequent hepatic failure and death when administered to individuals meeting appropriate laboratory criteria. METHODS Individuals with a potentially toxic acetaminophen ingestion according to serum acetaminophen levels were identi...

BACKGROUND Idiopathic pulmonary fibrosis is a chronic progressive disorder with a poor prognosis. METHODS We conducted a double-blind, randomized, placebo-controlled multicenter study that assessed the effectiveness over one year of a high oral dose of acetylcysteine (600 mg three times daily) added to standard therapy with prednisone plus azathioprine. The primary end points were changes bet...

N-Acetylcysteine is the drug of choice for the treatment of an acetaminophen overdose. It is thought to provide cysteine for glutathione synthesis and possibly to form an adduct directly with the toxic metabolite of acetaminophen, N-acetyl-p-benzoquinoneimine. However, these hypothese have not been tested in vivo, and other mechanisms of action such as reduction of the quinoneimine might be res...

BACKGROUND Acetylcysteine has been suggested as a beneficial treatment for idiopathic pulmonary fibrosis, although data from placebo-controlled studies are lacking. METHODS In our initial double-blind, placebo-controlled trial, we randomly assigned patients who had idiopathic pulmonary fibrosis with mild-to-moderate impairment in pulmonary function to receive a three-drug regimen of prednison...

Abstract Bi(III) ions electroreduction in the presence of N-acetylcysteine (ACYS)at nanostructured R-AgLAFE electrode has been studied by voltammetric and impedance measurements. The experimental data indicates multistage character process catalytic influence on rate. It was found that this is controlled chemical reaction Bi(III)–Hg(SR) 2 activecomplexes formation surface, which mediates electr...

there are a limited number of food and drug administration ( fda)-approved medications for the treatment of autism. meanwhile, oxidative stress and neuroinflammation are supposed to play a causative role in autism. n-acetylcysteine may provide cystine, a precursor for glutathione (gsh), which is an important antioxidant factor in the brain. we here report a child with autism, whose symptoms wer...

introduction it has long been known that ionizing radiation can lead to detrimental effects in normal cells. in this light, radioprotective chemicals have been used to decrease morbidity or mortality caused by ionizing irradiation. this study aimed to evaluate the radio-protective effect of n-acetylcysteineagainst radiation-induced mortality in male mice. materials and methods 52 healthy male m...

Acetylcysteine is a familiar friend of emergency physicians, intensivists, and medical toxicologists. There are 2 broad categories of acetaminophen toxicity that receive acetylcysteine therapy: acute single overdose ingestion and repeated supratherapeutic (“chronic”) ingestion. Since the 1970s, we have used acetylcysteine to reduce liver injury and death in patients with an acute overdose inges...

To assess the efficacy of an antibiofilm/antimicrobial agent combination, we incubated catheter segments colonized with one of six studied bacterial organisms in N-acetylcysteine, tigecycline, N-acetylcysteine-tigecycline, or saline. Segments were washed, sonicated, and cultured. N-acetylcysteine-tigecycline significantly decreased all viable biofilm-associated bacteria and was synergistic for ...