Background and Aims: Formaldehyde, a colorless aldehyde with pungent odor, has negative effects on systems of the body. Considering, there are a little data about protective substances against kidney damage induced by formaldehyde, the aim of the present study was to examine the effects of different doses of N-acetyl cysteine on biochemical and histopathological parameters in k...

background: liver ischemic insults are important sources of liver injuries leading to production of reactive oxygen species (ros) and mediating liver cell injury. glutathione mediated mechanisms are among the most important defense mechanisms of the liver; n-acetylcysteine (nac) provides cysteine for glutathione defense mechanisms. patients undergoing cardiac surgery are at increased risk of li...

BACKGROUND Oxidant/antioxidant imbalance may occur in the lungs of patients with chronic obstructive pulmonary disease (COPD). Glutathione is an important extracellular and intracellular thiol oxidant in the lungs. These studies were carried out to determine the effect of N-acetyl cysteine on thiol concentrations in plasma, bronchoalveolar lavage fluid, and lung tissue. METHODS Studies were c...

THEORETICAL AND EXPERIMENTAL STUDY OF STRUCTURE REACTIVITY RELATED TO METABOLISM TOXICITY PARACETAMOL. An experimental and theoretical approach on oxidative metabolism of paracetamol was applied for the pharmaceutical chemistry learning. Classical reactions, functional group identification, structural parameter, chemical reactivity using frontier orbitals Fukui index were used explaining main p...

N-acetyl-cysteine, N-acetylcysteine, N-acetyl cysteine, and N-acetyl-L-cysteine are all designations for the same compound, which is abbreviated as NAC. NAC is a precursor to the amino acid cysteine, which ultimately plays two key metabolic roles. Through its metabolic contribution to glutathione production, cysteine participates in the general antioxidant activities of the body. Through its ro...

BACKGROUND Increased levels of reactive oxygen species during and after surgery may affect inflammatory response, post-operative adhesion molecule formation, and hemodynamic stability. The glutathione redox cycle is an important regulator in oxidative stress and its reduced forms scavenge free radicals. N-acetyl cysteine, a precursor of reduced glutathione, is considered as a potentially therap...

S-Nitrosothiols or thionitrites with the general formula RSNO are formally composed of the nitrosyl cation (NO+) and a thiolate (RS-), the base of the corresponding acids RSH. The smallest S-nitrosothiol is HSNO and derives from hydrogen sulfide (HSH, H2S). The most common physiological S-nitrosothiols are derived from the amino acid L-cysteine (CysSH). Thus, the simplest S-nitrosothiol is S-ni...

Continuous improvements of cell culture media are required in order to ensure high yield and product quality. However, some components can be instable lead detrimental effects on bioprocess performances. l-cysteine is an essential amino acid commonly used media. Despite its beneficial effect recombinant protein production, cases, this component responsible for microheterogeneity. In context, al...

Background: Acetaminophen is a popular antipyretic and analgesic medication worldwide; however, its therapeutic window narrow, which may lead to overdose or toxicity. This study was conducted assess the correlation between serum acetaminophen levels before 4 hours after acute toxicity with this drug. The objective of test validity level arrive at clinical decision on acetaminophen. Methods: cro...