To the Editor: We read with great interest the article entitled, “A Case of Acute Myocardial Infarction Induced by Selective Cyclooxygenase-2 Inhibitor” by Seo et al.[1] The authors have shown a correlation of aceclofenac intake with the myocardial infarction. This is really important information to be noted as aceclofenac or any nonsteroidal anti-inflammatory drugs (NSAIDS) of this group were ...

The current study involves the evaluation of factors that influence the transcorneal permeation of aqueous drops of aceclofenac ophthalmic formulation through freshly excised goat, sheep, and buffalo corneas. Aceclofenac formulation with different concentrations 0.1-0.5% (w/v) and with different pH and different preservatives, was taken into account. The amount of drug permeated from different ...

Non-steroidal antiinflammatory drugs are routinely prescribed for the patients with rheumatic disease and such patients are at increased risk of serious gastrointestinal complications, when non-steroidal antiinflammatory drugs administered by oral route. The aim of the present study was to develop and characterized a vesicular drug carrier system (proliposome) for topical delivery of aceclofena...

a topical preparation containing aceclofenac was developed using an o/w microemulsion system. isopropyl myristate was chosen as the oil phase as it showed a good solubilising capacity. pseudo-ternary phase diagrams were used to obtain the concentration ranges of the oil, surfactant (labrasol) and co-surfactant (plurol oleique) for microemulsion formation. five different formulations were formul...

A topical preparation containing aceclofenac was developed using an o/w microemulsion system. Isopropyl myristate was chosen as the oil phase as it showed a good solubilising capacity. Pseudo-ternary phase diagrams were used to obtain the concentration ranges of the oil, surfactant (Labrasol) and co-surfactant (plurol oleique) for microemulsion formation. Five different formulations were formul...

OBJECTIVE To analyze the effects on pain, function, and safety of aceclofenac compared with other nonsteroidal anti-inflammatory drugs (NSAIDs) or pain relief medications in patients with osteoarthritis. MATERIAL AND METHODS Two investigators independently searched the database. We included randomized controlled trials evaluating efficacy and/or safety of aceclofenac compared with control int...

The aim of the study was to develop UV-spectrophotometric and RP-HPLC methods for the simultaneous analysis of paracetamol and aceclofenac in marketed tablets. The methods were validated in terms of linearity, accuracy (% Recovery), precision (inter day, intraday and reproducibility) and robustness. Both the methods were linear (R = 0.997-0.999 for UV method and 0.999 for RP-HPLC method) and ac...

Department of Pharmaceutics, Department of Phytopharmacy and Pharmacognosy, JSS College of Pharmacy, Udhagamandalam-643001, Tamil Nadu, India Abstract The objective of present work was to prepare a dual release drug delivery systems comprising fast and delayed release pattern using solid dispersion and pellets of the aceclofenac to achieve a desired in vitro and in vivo profile. Aceclofenac sol...

INTRODUCTION Aceclofenac, a NSAID is widely used in the treatment of pain and inflammation associated with osteoarthritis. Nabumetone, a recently developed preferential cyclo-oxygenase 2 inhibitor has also proved to be equally effective. The present study was undertaken to evaluate the 'real better' drug, amongst these with better efficacy and gastro-intestinal tolerability as well. METHODS F...

The aim of the present investigation was to compare pharmacokinetic profile (bioavailability) of aceclofenac by transdermal and oral application. Nanoemulsion, nanoemulsion gel and marketed tablet (Aceclofar®) were subjected to pharmacokinetic (bioavailability) studies on Wistar male rats. Several pharmacokinetic parameters like Cmax, tmax, AUC0→t, AUC0→α, Ke, and T1/2 were determined for each ...