Major histocompatibility complex (MHC) class I molecules present thousands of peptides to allow CD8+ T cells to detect abnormal intracellular proteins. The antigen-processing pathway for generating peptides begins in the cytoplasm, and the MHC molecules are loaded in the endoplasmic reticulum. However, the nature of peptide pool in the endoplasmic reticulum and the proteolytic events that occur...

M. Susan Marquis and Stephen H. Long are senior economists at RAND, Washington, DC. The authors would like to thank the Florida Agency for Health Care Administration and the Department of Health and Rehabilitative Services for providing data, Ellen Harrison for expertly constructing the analysis files and Nancy Allen for assistance with Medicaid data. The authors are also grateful to project of...

cd200/cd200R are highly conserved type i paired membrane glycoproteins that belong to the ig superfam‐ ily containing a two immunoglobulin ‐like domain (v, c). cd200 is broadly distributed in a variety of cell types, whereas CD200R is primarily expressed in myeloid and lymphoid cells. They fulfill multiple functions in regulating inflamma‐ tion. the interaction between cd200/cd200R results in a...

The subject literature supports that patients with Traumatic Brain Injury (TBI) have a reduction in information processing speed and that this may contribute to deficits in attention, orientation and executive functioning including a deficit in mental flexibility, planning, self-monitoring, and problem solving. Therefore the aim of the present study was to remediate neuropsychological deficits ...

The mechanism of apoptosis has been extensively characterized over the past decade, but little is known about alternative forms of regulated cell death. Although stimulation of the Fas/TNFR receptor family triggers a canonical ‘extrinsic’ apoptosis pathway, we demonstrated that in the absence of intracellular apoptotic signaling it is capable of activating a common nonapoptotic death pathway, w...

Sacral neuromodulation (SNM) therapy has revolutionized the management of many forms of anal incontinence, with an expanded use and a medium-term efficacy of 75% overall. This review discusses the technique of SNM therapy, along with its complications and troubleshooting and a discussion of the early data pertaining to peripheral posterior tibial nerve stimulation in incontinent patients. Futur...

We present an indexing scheme that is capable of answering a broad range of complex top-k queries that contain a scalar product between two vectors when one of the vectors is present in the database, while the other one arrives at query time. Specifically we provide indexing facilities for the top-k closest points below (above) a hyperplane and the top-k farthest points below (above) a hyperpla...

everal researchers have reported that CT perfusion studies have been helpful in diagnosing and managing acute ischemic stroke in large numbers of patients. Adding CT perfusion to the imaging protocol improves the accuracy of a stroke diagnosis and is successful in most cases. Incorporating perfusion may even potentially reduce inpatient costs through improvements in management. Research has sho...