Telomere shortening represents a causal factor of cellular senescence. At the same time, several lines of evidence indicate a pivotal role of oxidative DNA damage for the aging process in vivo. A causal connection between the two observations was suggested by experiments showing accelerated telomere shorting under conditions of oxidative stress in cultured cells, but has never been studied in v...

Chronic obstructive pulmonary disease (COPD) is a disease that usually presents clinically at an advanced age, after years of smoking cigarettes. It is usually believed that aging and its biological consequences are important mechanisms in the disease pathogenesis. This concept has maintained the focus of studies on COPD in old-age individuals. Here we analyze the possible role of aging from a ...

It is a well known fact that the world population has been aging since mid-20th century. The number of older people aged 60 years and above has more than quadrupled since 1950’s and older people’s share of the world population reached 11.7 percent in 2013 [1]. The older population itself is also aging. In 2013, 14 percent of the older population consisted of those who were 80 years of age or ol...

The aging process contributes to the sensory evolution of alcoholic beverages, producing changes in color and flavor final product. Traditionally, has occurred by storing beverages wooden barrels for several months or years. To meet demand aged there is a need large storage areas, number barrels, and, consequently, volumes stored Evaporation losses can also occur. In addition reactions beverage...

Many studies analyzed in depth how aging affects aggregate economic performance. But analyses of these effects on the employment structure are scarce and they do not consider that consumption patterns, the supply of goods and services, and also sectoral labor productivity are all likely to adjust to aging and will change. Hence, regression analysis of sectoral employment shares is proposed that...

Peroxisomes are ubiquitous eukaryotic organelles, which perform a plethora of functions including hydrogen peroxide metabolism and β-oxidation of fatty acids. Reactive oxygen species produced by peroxisomes are a major contributing factor to cellular oxidative stress, which is supposed to significantly accelerate aging and cell death according to the free radical theory of aging. However, relat...

Here, we provide a brief review of the mechanistic connections between immunity and aging-a fundamental biological relationship that remains poorly understood-by considering two intertwined questions: how does aging affect immunity, and how does immunity affect aging? On the one hand, aging contributes to the deterioration of immune function and predisposes the organism to infections ("immuno-s...