INTRODUCTION: Thyroid ectopia can be found at the site of thyroid origin in the floor of the mouth, or anywhere along its path of embryological descent, thus reflecting the normal migration of thyroid progenitor cells. The most frequent sites of ectopic thyroid tissue are lingual, sublingual, thyroglossal and laryngotracheal, with ectopic intratracheal thyroid (EITT) accounting for a small mino...

Congenital hypothyroidism (CH) is the most frequent endocrine disease in infants, affects about 1 in 3,000 newborns and is characterized by elevated levels of thyroidstimulating hormone (TSH) as a consequence of reduced thyroid function. It is also one of the most common preventable causes of cognitive and motor deficits. Prevention of CH is based on carrier identification, genetic counseling a...

CONTEXT Heterozygous inactivating PAX8 mutations cause congenital hypothyroidism. Although more than 30 mutation carriers have been reported, no histological examination of the thyroid has been conducted. OBJECTIVE The objective of this study was to document the histological characteristics of the thyroid tissue harboring a PAX8 mutation. SUBJECTS AND METHODS The patient was a 40-yr-old fem...

Sir, I read with interest the article by Tindall, Griffiths & Penn.' They conclude that 'scintigraphy has been shown to be of little practical value in... patients with hypothyroidism and therefore should not be requested'. This does not hold true for neonates who are identified by newborn screening to have connatal hypothyroidism, i.e. thyrotrophin above 7 mU/l and T4 below 6 ug/dl, as defined...

Anaplastic thyroid carcinoma (ATC) remains one of the most lethal human cancers. We hypothesized that sorafenib, a multikinase inhibitor of the BRaf, vascular endothelial growth factor receptor-2, and platelet-derived growth factor receptor-beta kinase, would decrease tumor growth and angiogenesis in an orthotopic model of ATC. The in vitro antiproliferative and proapoptotic effects of sorafeni...

thyroid tissue located within the upper airway has received only sparse attention in the english literature. aberrant benign thyroid masses may present as either an unrelated autopsy finding or with symptoms such as dyspnea, hemoptysis or adult -onset asthma. there is no place for medical management in the therapy of these lesions, although the appropriate surgical procedure is not clearly esta...

To the Editor, International Journal of Anatomical Variations: I read the recently published article “An incidental finding of the accessory inferior thyroid artery” by Jiri Sedy [1] with keen interest and found the article very enlightening. The authors have provided useful information regarding the variant thyroid artery, which will be helpful for the anatomists and mostly surgeons working on...

Background Ovarian tissue cryopreservation is an option for patients who require immediate gonagonadotoxic treatment of cancers. when there is insufficient time to conduct ovulation induction This procedure can be used in patients with genetic mutations with a high risk for premature ovarian failure.This strategy is the only option for fertility preservation in prepubertal girls or in women who...