نتایج جستجو برای: aberrant phenotype
تعداد نتایج: 189478 فیلتر نتایج به سال:
Neutrophils have emerged as important regulators of innate and adaptive immune responses. Recent evidence indicates that neutrophils display marked abnormalities in phenotype and function in various systemic autoimmune diseases, and may play a central role in initiation and perpetuation of aberrant immune responses and organ damage in these conditions. This review discusses the putative roles t...
Neurodegeneration, a result of multiple dysregulatory events, is a lengthy multistep process manifested by accrual of mutant variants and abnormal expression, posttranslational modification, and processing of certain proteins. Accumulation of these dysregulated processes requires a mechanism that maintains their functional stability and allows the evolution of the neurodegenerative phenotype. I...
Many mammals show epidermal patterning, as seen in alternating mouse tail scales and the microtopography of human skin surface. However, mechanisms underlying development such patterning are poorly understood. Here, we that type XVII collagen (COL17), a niche for stem cells, is factor determining patterning. Col17-null mice exhibit slender scales, condition alleviated by COL17 overexpression. A...
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