Polymers like cellulose (MethocelTM K100MPRCR, K15MPRCR and E4MCR) at different proportions (15-35%) were used to slow the release of theophylline (100 mg) from capsules. Volumetric method for powder filling capsules was used to prepare the capsules. Drug release from capsules was performed using apparatus 1, at 100 rpm and 900 mL of intestinal medium without enzymes (pH 7.5), at 37 °C, followi...

A key phase in the development of intelligently designed nanoparticle delivery vehicles for new therapeutic agents is to gain an understanding of their interaction with tissues and cells. We report a series of in vitro and in vivo experiments aimed at tracking a potential delivery vehicle for therapeutic agents, including vaccine peptides and drugs derived from poly(methacrylic acid) hydrogel c...

Many authors have studied the local dynamics of holomorphic maps in C around a fixed point; see, for example, [4; 6] for an introduction to this field and known results. Most of the results are obtained under the assumption that the linear part of the map at the fixed point is diagonalizable. There are few results in the nondiagonalizable case. In [8], Coman and Dabija studied a special map wit...

The nontarget effects of temephos (as Abate 4E, 44.6% active ingredient) on fiddler crabs were examined on the salt marsh at Bombay Hook National Wildlife Refuge, near Dover, DE. Six 170 x 170-m plots were established; 3 were sprayed on 4 occasions at a rate of 1.5 fl oz/acre (0.054 kg active ingredient/ha) and 3 were controls. On each plot, marsh fiddler crab (Uca pugnax) populations were moni...

Coated hard capsules are becoming increasingly important for a number of reasons such as administration of new active ingredients, oral vaccination, colon drug delivery or their use in preclinical and clinical trials. The independency of coating composition on capsules filling is the major advantage of this dosage form. In our study, two types of hard capsules (gelatin and hypromellose) were co...

The hydrodynamic interaction between two nonspherical capsules suspended in a simple shear flow is studied numerically using a front-tracking method. The capsules are enclosed by thin shells which develop in-plane tensions and bending moments due to a preferred three-dimensional unstressed configuration. Computations are performed for capsules with spherical, oblate spheroidal, and biconcave un...