نتایج جستجو برای: aat
تعداد نتایج: 1220 فیلتر نتایج به سال:
α1-Antitrypsin (AAT) is a member of the serine proteinase inhibitor family that impedes the enzymatic activity of serine proteinases, including human neutrophil elastase, cathepsin G and neutrophil proteinase 3. Here, we expressed recombinant AAT by fusing the intact AAT gene to the constant region of IgG1 to generate soluble recombinant AAT-Fc protein. The recombinant AAT-Fc protein was produc...
Alpha1-Antitrypsin (AAT), an acute-phase protein, is the prototypic member of the serpin superfamily and a major inhibitor of serine proteases such as neutrophil elastase and protease 3. As an acute-phase protein, AAT is thought to play an important role in limiting host tissue injury by proteases at sites of inflammation. The clinical importance of AAT is highlighted in individuals with inheri...
Human alpha 1-antitrypsin (AAT) cDNA was obtained from HepG2 cell lines. After PCR and construction of expression vector pPICZα-AAT, human AAT was expressed in the yeast Pichia pastoris (P.pastoris) in a secretary manner and under the control of inducible alcohol oxidase 1 (AOX1) promoter. The amount of AAT protein in medium was measured as 60 mg/l 72 hr after induction with methanol. Results i...
A sulfated alpha1-antitrypsin (AAT), thought to be a default secretory pathway marker, is not stored in secretory granules when expressed in neuroendocrine PC12 cells. In search of a constitutive secretory pathway marker for pancreatic beta cells, we produced INS-1 cells stably expressing wild-type AAT. Because newly synthesized AAT arrives very rapidly in the Golgi complex, kinetics alone cann...
Aspartate aminotransferase (AAT), an enzyme interconverting glutamate and aspartate, has been suggested to be a marker for glutamatergic and/or aspartatergic neurons. However, AAT, glutamate, and aspartate are also involved in cellular metabolism, e.g., the malate-aspartate shuttle. To investigate the extent to which AAT might be involved in these several functions in retina, the distribution o...
Interaction of Human Serum alpha-1-Antitrypsin and Low Density Lipoprotein "a Perspective to the Relation of Liver and Heart diseases" A.S. Lotfi PhD1*, F. Faraji MSc2, A. Allameh PhD3, A. MohsenifarMSc4, HR. Rashdi Nejad MD5, M. Mahmoodi PhD6 1- Associate Professor in Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modarres University, Tehran, Iran 2- MSc. in Clinical Bioch...
The rationale of α1-antitrypsin (AAT) augmentation therapy to treat progressive emphysema in AAT-deficient patients is based on inhibition of neutrophil elastase; however, the benefit of this treatment remains unclear. Here we show that clinical grade AAT (with elastase inhibitory activity) and a recombinant form of AAT (rAAT) without anti-elastase activity reduces lung inflammatory responses t...
α1-antitrypsin (AAT), a circulating glycoprotein that rises during acute phase responses and healthy pregnancies, exhibits immunomodulatory properties in several T-cell-dependent immune pathologies. However, AAT does not directly interfere with T-cell responses; instead, it facilitates polarization of macrophages and dendritic cells towards M2-like and tolerogenic cells, respectively. AAT also ...
Alpha-1-antitrypsin (AAT) is a hepatic stress protein with protease inhibitor activity. Recent evidence indicates that ischemic or toxic injury can evoke selective changes within kidney that resemble a hepatic phenotype. Hence, we tested the following: i) Does acute kidney injury (AKI) up-regulate the normally renal silent AAT gene? ii) Does rapid urinary AAT excretion result? And iii) Can AAT'...
BACKGROUND Animal-assisted therapy (AAT) is claimed to have a variety of benefits, but almost all published results are anecdotal. We characterized the resident population in long-term care facilities desiring AAT and determined whether AAT can objectively improve loneliness. METHODS Of 62 residents, 45 met inclusion criteria for the study. These 45 residents were administered the Demographic...
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