Based on two integration steps, an optimization framework is proposed in this work for the synthesis and design of complex distillation sequence. The first step is to employ heat integration in sequence and reduce the heat consumption and total annual cost of the process. The second one is to increase the exergetic efficiency of sequence by generating power in implemented expanders in sequence....

The asymptotic behaviour of the sequence with general term $P_n=(varphi(1)+varphi(2)+cdots+varphi(n))/(1+2+cdots+n)$, is studied which appears in the studying of coprime integers, and an explicit bound for the difference $P_n-6/pi^2$ is found.

We introduce a matricial Toeplitz transform and prove that the Toeplitz transform of a second order recurrence sequence is another second order recurrence sequence. We investigate the injectivity of this transform and show how this distinguishes the Fibonacci sequence among other recurrence sequences. We then obtain new Fibonacci identities as an application of our transform.

tenecteplase is a variant of tissue plasminogen activator (t-pa) which has better pharmacokinetic properties and more selective thrombolytic activity. in the present study, we describe a rapid method to introduce three sets of mutation into defined positions in t-pa cdna by a site-directed mutagenesis based on a megaprimer pcr approach to produce tenecteplase coding sequence where amino acids a...

Background: Deoxyribozymes (Dzs) can play a role as gene expression inhibitors at mRNA level. Among Dzs, the 10-23 deoxyribozyme has significant potentials for treatment of diseases. Designed Dz includes a catalytic core made of 15 deoxyribonucleotides and two binding arms consisted of 6-12 nucleotides for site specific binding to target RNA and hydrolysis. The enzyme has characteristic feature...

Truck-Shovel fleet, as the most common transportation system in open-pit mines, has a significant part of mining costs, for which optimal management can lead to substantial cost reductions. Among the available dispatch mathematical models, the multi-stage approach is well suited for allocating trucks to respected shovels in a dynamic dispatching program. However, with this kind of modeling sequ...

We describe Protogene, a server that can turn a protein multiple sequence alignment into the equivalent alignment of the original gene coding DNA. Protogene relies on a pipeline where every initial protein sequence is BLASTed against RefSeq or NR. The annotation associated with potential matches is used to identify the gene sequence. This gene sequence is then aligned with the query protein usi...

in this paper we introduce entire sequence spaces defined by a sequence of modulus functions . we study some topological properties of these spaces and prove some inclusion relations.