a l t h o u g h m o s t c o m p a n i e s s p e n d l e s s o n p r o d u c t d e s i g n, e x p e r i e n c e s h o w s t h a t, t h e s e c o m p a n i e s h a v e t o p a y h i g h e r c o s t s d u e t o p r o d u c t i o n p r o b l e m s o r l o s s o f m a r k e t. l i t e r a t u r e s t u d i e s s h o w t h a t t h e d e s i g n f o r s i x s i g m a i s a p o w e r f u l a p p r o a ...

parkinson disease (pd) is the most common movement disorder with progressive degeneration of midbrain dopaminergic neurons for which current treatments afford symptomatic relief with no-prevention of disease progression. due to the neuroprotective property of the nigella sativa bioactive compound thymoquinone (tq), this study was undertaken to evaluate whether tq could improve behavioral and ce...

new derivatives of 2-[2-(2-chlorophenoxy)phenyl]-1,3,4-oxadiazole as candidates for agonistic effect on benzodiazepine receptors were synthesized. conformational analysis and superimposition of energy minima conformers of the novel compounds on estazolam, a known benzodiazepine agonist, revealed that the main proposed benzodiazepine pharmacophores were well matched. in pharmacological evaluatio...

background: h e r2/ n eu i so n e o ftheepi de rmalg r owth f actor r e c e pt o rsfami l i e s andsee m stohaveprognosticsignificanceofsomesolid t umors.theo b jecti v eof thisstu d yistoevaluatet h epossi b ilityofher2ex p ressioningastricca n cersand the p o s si b le r e lat i o n ship o fh e r2withtumo r ’scli n icopat h o l o gicpara m e te r sa n d a l s oits pr o gno s tic r o l e .   m...

benzodiazepines are useful drugs for treatment of sleep disorders, anxiety, seizure cases and skeletal muscle cramps. some derivatives of 2-(2-phenoxy) phenyl-1, 3, 4-oxadiazole were synthesized as benzodiazepine receptor agonists. conformational analysis and superimposition of energy minima conformers of the compounds on estazolam, a known benzodiazepine agonist, reveal that the main proposed ...

objective(s) 7-prenyloxycoumarins including 7-isopentenyloxycoumarin, auraptene and umbelliprenin, and herniarin have been widely recognized as bioactive coumarins. this paper presents the ways to synthesis these compounds. materials and methods 7-prenyloxycoumarins were synthesized by reaction between 7-hydroxycoumarin (' m) and relevant prenyl bromides (1.5 m) in acetone at room temperat...