OBJECTIVE This study tested whether the two-body wear of monolithic zirconia and their corresponding enamel antagonists was higher compared to monolithic alloy and veneered zirconia. MATERIALS AND METHODS Cylindrical specimens (N = 36, n = 6) were prepared out of (A) veneered zirconia (VZ), (B) glazed zirconia using a glaze ceramic (GZC), (C) glazed zirconia using a glaze spray (GZS), (D) man...

KRAS mutations are primary genetic lesions leading to pancreatic cancer. The promoter of human KRAS contains a nuclease-hypersensitive element (NHE) that can fold in G4-DNA structures binding to nuclear proteins, including MAZ (myc-associated zinc-finger). Here, we report that MAZ activates KRAS transcription. To knockdown oncogenic KRAS in pancreatic cancer cells, we designed oligonucleotides ...

Pheochromocytomas in multiple endocrine neoplasia type 2 (MEN-2) express phenylethanolamine N-methyltransferase (PNMT), the enzyme that catalyzes conversion of norepinephrine to epinephrine, whereas those in von Hippel-Lindau (VHL) syndrome do not. Consequently, pheochromocytomas in MEN-2 produce epinephrine, whereas those in VHL syndrome produce mainly norepinephrine. This study examined wheth...

Neurons and glia cells are differentiated from neural stem/progenitor cells (NSCs/NPCs) during brain development. Concomitant activation of JAK/STAT and NOTCH1 signaling is required for gliogenesis, a process to generate glia cells to ensure proper brain functions. NOTCH1 signaling is down-regulated during neurogenesis and up-regulated during gliogenesis. However, the underlying mechanism remai...

Six-membered ring cyclohexane derivatives with 2 oxygen (1,4-dioxane or p-dioxane) and 3 (1,3,5-trioxane) atoms have been used as organic molecules in the synthesis of zeolites omega (MAZ framework type) ECR-1 (EON type). Both yield zeolite at moderate temperatures a composition aluminum distribution similar to those obtained more standard organics such tetramethylammonium cation. If preparatio...

Vascular endothelial growth factor (VEGF)-C plays an important role in lymphangiogenesis; however, functional responses of lymphatic vessels to VEGF-C have not been characterized. We tested the hypothesis that VEGF-C-induced activation of VEGF receptor (VEGFR)-3 increases lymphatic pump output. We examined the in vivo pump activity of rat mesenteric collecting lymphatics using intravital micros...

Abstract The position of the Banwell Bone Cave mammal assemblage zone (MAZ) in mammalian biostratigraphy British Isles has been focus debate for decades. Dominated by fauna typical cold environments it was originally linked to marine oxygen isotope stage (MIS) 4 stadial (ca. 72–59 ka). Subsequently argued that MAZ more likely relates temperate interstadial MIS 5a 86–72 It is envisioned “cold fa...

Hepatitis B virus (HBV) X protein (HBx), a trans-regulator, is frequently expressed in truncated form without carboxyl-terminus in hepatocellular carcinoma (HCC), but its functional mechanisms are not fully defined. In this report, we investigated frequency of this natural HBx mutant in HCCs and its functional significance. In 102 HBV-infected patients with HCC, C-terminal truncation of HBx, in...