The immunophenotype of Reed-Sternberg (RS) cells in Hodgkin's disease (HD) has not been clearly defined, partly owing to difficulties in studying RS cells in cell suspensions or identifying them with certainty in frozen sections. We studied the immunophenotype of RS cells with a recently developed plastic section immunohistochemical technique on acetone-fixed tissues that affords superior morph...

M(1) muscarinic (M(1)AChRs) and B(2) bradykinin (B(2)Rs) receptors are two PLCbeta-coupled receptors that mobilize Ca(2+) in nonexcitable cells. In many neurons, however, B(2)Rs but not M(1)AChRs mobilize intracellular Ca(2+). We have studied the membrane organization and dynamics underlying this coupling specificity by using Trp channels as biosensors for real-time detection of PLCbeta product...

OUT THE NORTHERN LOWLANDS OF MARS? N. E. Putzig1, R. J. Phillips1, J. W. Head2, B. A. Campbell3, A. F. Egan1, J. J. Plaut4, L. M. Carter3, R. Seu5, and the SHARAD Team. 1Southwest Research Institute, Boulder, CO 80302 USA (email: [email protected]); 2Dept. of Geological Sciences, Brown Univ., Providence, RI 02912 USA; 3National Air and Space Museum, Smithsonian Institution, Washington, DC 20...

THE MOON MINERALOGY MAPPER. J.-Ph. Combe, T. B. McCord, G. Y. Kramer, C. M Pieters, L. A. Taylor, N. E. Petro, J. W Boardman, J. F Mustard, J. M Sunshine, S. Tompkins , R.O. Green and the M Team. The Bear Fight Center, Winthrop, WA, (jean-philippe_combe @ bearfightcenter.com). Brown University, Providence, RI, USA. University of Tennessee, Knoxville, TN, USA. Goddard Space Flight Center, Greenb...

Resynthesized (RS) oilseed rape (Brassica napus L.) is potentially of great interest for hybrid breeding. However, a major problem with the direct use of RS B. napus is the quality of seed oil (high level of erucic acid) and seed meal (high glucosinolate content), which does not comply with double-low quality oilseed rape. Thus, additional developments are needed before RS B. napus can be intro...

The Rockefeller University Press $30.00 J. Exp. Med. Vol. 205 No. 13 2985-2994 www.jem.org/cgi/doi/10.1084/jem.20082053 2985 B cells undergo a random process of V(D)J recombination to generate the many distinct receptors needed to recognize a vast array of antigens. An inevitable consequence of this random process is the production of autoreactive B cells ( 1 ). An important mechanism for toler...

The Rockefeller University Press $30.00 J. Exp. Med. Vol. 205 No. 13 2985-2994 www.jem.org/cgi/doi/10.1084/jem.20082053 2985 B cells undergo a random process of V(D)J recombination to generate the many distinct receptors needed to recognize a vast array of antigens. An inevitable consequence of this random process is the production of autoreactive B cells ( 1 ). An important mechanism for toler...

Background: We explored the effect of vitamin D receptor gene (VDR) polymorphisms in response to PEG-IFN treatment in Egyptian chronic hepatitis B (CHB) patients. Methods: Two hundred hepatitis B virus (HBV) patients (42.3±10.7 years) on PEG-IFN α-2a (180 μg /kg for 48 weeks) and one hundred control subjects (37.3 ±12 years) were enrolled in the study. Vitamin D levels a...