OBJECTIVE To describe clinical and neuroimaging (SPECT) characteristics of Brazilian patients with Parkinson's disease (PD) and mutations in PARK2 or PARK8 genes. METHOD A total of 119 patients meeting clinical criteria for PD were evaluated. RESULTS Of all patients studied, 13 had mutations in either PARK2 (n=9) or PARK8 genes (n=4). No statistically significant differences in clinical cha...

PURPOSE Pallidoreticular damage was defined by lesions involving both the pallidum and the substantia nigra and was only reported in four cases after CO intoxication. CASE REPORT We report a patient with initial consciousness disturbances followed by parkinsonian features after carbon monoxide intoxication. The unique features in this patient included primary globus pallidus hemorrhage follow...

An 84-year-old woman underwent a dopamine transporter (DAT) study to investigate a non-levodopa-responsive parkinsonism. A SPECT brain scan was conducted four hours after intravenous administration of 1110 MBq (megabecquerels) equivalent to 30 mCi (millicuries) of 99mTc–TRODAT-1. The study revealed a significant uptake deficit of radiopharmaceuticals in the striatum. The semi-quantitative analy...

We evaluated the diagnostic accuracy of SPECT imaging using [(99m)Tc]TRODAT-1 (TRODAT), a relatively inexpensive technetium-labeled dopamine transporter ligand, in distinguishing 29 patients with early PD from 38 healthy volunteers. Mean TRODAT uptake values were significantly decreased in the caudate (p=0.0097) and anterior and posterior putamen (p < 0.0001) of PD patients compared to controls...

Introduction: Quantitative evaluation is recommended to improve diagnostic ability and serial assessment of dopamine transporter (DAT) density scans. We decided to compare the ordered subsets expectation-maximization (OSEM) with filtered back-projection (FBP), and to investigate the impact of different iteration and cut-off frequencies on SBR values. Methods</stro...

Parkinson’s disease (PD) is one of the most common neurological disorder diseases which takes place when brain cells gradually die. PD considered a challengeable because similarities between and other disorders. For this reason, there are several ways to diagnose PD. Nuclear medicine can be solution distinguish some disorders The aim review understand differences three radiopharmaceuticals used...