The biodistribution and removal from plasma (measured as fractional clearance rate, FCR, per hour) of native and oxidatively modified 99mtechnetium-labeled beta-very low density lipoprotein (99mTc-beta-VLDL) were investigated in hypercholesterolemic (HC) and control (C) three-month old New Zealand rabbits. The intracellular accumulation of beta-VLDL labeled with 99mTc was studied in vitro in TH...

UNLABELLED This study was designed to compare the tracer kinetics between 99mTc-sestamibi and 99mTc-tetrofosmin in a heterogeneous group of 24 patients admitted for routine perfusion imaging. METHODS Twelve patients were studied with 99mTc-tetrofosmin and 12 with 99mTc-sestamibi. In each group, six patients had a low likelihood for coronary artery disease, and six patients had angiographicall...

99mTc-[bis (dimethoxypropylphosphinoethyl)-ethoxyethylamine (PNP5)]-[bis (N-ethoxyethyl)-dithiocarbamato (DBODC)] nitride (N-PNP5-DBODC or N-DBODC5) is a new monocationic myocardial perfusion tracer. We sought to compare the myocardial uptake and clearance kinetics and organ biodistribution of 99mTc-N-DBODC5 with 99mTc-sestamibi and 99mTc-tetrofosmin. Methods: Seventy-five anesthetized Sprague–...

Secure determination of the binding of 99mTc-radiopharmaceuticals to plasma (P) and blood cell (BC) constituents can help to understand the biodistribution of radiophamaceuticals. The reported precipitation studies of blood with radiopharmaceuticals have shown that the results can not be easily compared between studies. We decided to determine the "gold standard" concentration of trichloroaceti...

Thiamazole inhibits the thyroid hormone synthesis and does not inactivate existing thyroxine triiodothyronine that circulate in blood. In this paper electrochemical behavior was monitored by cyclic voltammetry on glassy carbon (GC) electrode absence presence of sodium pertechnetate (99mTc). The influence different concentrations without radiopharmaceutical 99mTc, effect number scan cycles, 99mT...

Síndrome de bridas amnióticas (SBA), una anomalía congénita caracterizada por constricciones y/o amputaciones completas extremidades a causa las durante el embarazo. En los casos más graves están asociadas con otras malformaciones como craneofaciales. La patogenia del SBA es controversial baja incidencia. El diagnóstico prenatal oscila entre 29-50% casos. Presentamos caso paciente brida amnióti...

Cerebral amyloid angiopathy (CAA) is characterized by the deposition of amyloid aggregates in the walls of the cerebral vasculature. Recently, the development of molecular imaging probes targeting CAA has been attracting much attention. We previously reported the 99mTc-hydroxamamide (99mTc-Ham) complex with a bivalent benzothiazole scaffold as a binding moiety for amyloid aggregates ([99mTc]BT2...

Background. Topical diagnosis of primary hyperparathyroidism (PHPT) remains an urgent problem due to the high incidence persistence and recurrence after surgical treatment. At preoperative stage, a search for parathyroid hormone hyperproduction source is performed using instrumental methods: ultrasound, scintigraphy glands (PTG) multislice computed tomography (MSCT). The cause PHPT parathyroide...

Purpose: To demonstrate a rare clinical case of early recurrence verified primary genital lymphoma and the possibility 99mTc-1-Thio-D-glucose (99mTc-TG) SPECT/CT using to brain metastasis diagnosis. Material methods: A patient with diagnosis diffuse large B-cell underwent magnetic resonance imaging (MRI) assess extent disease. Post-treatment follow-up included 18F-FDG PET/CT. diagnose metastasi...

for quantum technologies G. Brida, I. P. Degiovanni, M. Genovese, F. Piacentini, P. Traina, A. Della Frera, A. Tosi, A. Bahgat Shehata, C. Scarcella, A. Gulinatti, M. Ghioni, S. V. Polyakov, A. Migdall, and A. Giudice Istituto Nazionale di Ricerca Metrologica-I.N.RI.M., Strada delle Cacce 91, 10135 Torino, Italy Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy Joint Quant...