نتایج جستجو برای: 9 cis retinoic acid

تعداد نتایج: 1222320  

Journal: :Journal of lipid research 1999
M V Gamble E Shang R P Zott J R Mertz D J Wolgemuth W S Blaner

We have identified a retinol dehydrogenase (cRDH) that catalyzes the oxidation of 9-cis- but not all-trans-retinol and proposed that this enzyme plays an important role in synthesis of the transcriptionally active retinoid, 9-cis-retinoic acid. There is little information regarding either the biochemical properties of cRDH or how its 9-cis-retinol substrate is formed. We now report studies of t...

Journal: :Cancer research 1995
D R Shalinsky E D Bischoff M L Gregory M M Gottardis J S Hayes W W Lamph R A Heyman M A Shirley T A Cooke P J Davies

Retinoids are promising agents for therapy of squamous cancers. In vitro, retinoids decrease expression of differentiation markers in head and neck squamous carcinoma cells. Little information is available on effects of retinoids on head and neck squamous carcinoma cell xenograft growth in vivo. To address this issue, head and neck squamous carcinoma cells (line 1483) were established as xenogr...

Journal: :Journal of cell science 2004
Xiao-Feng Lin Bi-Xing Zhao Hang-Zhi Chen Xiao-Feng Ye Chao-Yi Yang Hai-Ying Zhou Ming-Qing Zhang Sheng-Cai Lin Qiao Wu

Retinoid X receptor (RXR) plays a crucial role in the cross talk between retinoid receptors and other hormone receptors including the orphan receptor TR3, forming different heterodimers that transduce diverse steroid/thyroid hormone signaling. Here we show that RXRalpha exhibits nucleocytoplasmic shuttling in MGC80-3 gastric cancer cells and that RXRalpha shuttling is energy-dependent through a...

Journal: :Journal of immunology 2005
Reuven Rasooly Gertrud U Schuster Jeffrey P Gregg Jia-Hao Xiao Roshantha A S Chandraratna Charles B Stephensen

Vitamin A affects many aspects of T lymphocyte development and function. The vitamin A metabolites all-trans- and 9-cis-retinoic acid regulate gene expression by binding to the retinoic acid receptor (RAR), while 9-cis-retinoic acid also binds to the retinoid X receptor (RXR). Naive DO11.10 T lymphocytes expressed mRNA and protein for RAR-alpha, RXR-alpha, and RXR-beta. DNA microarray analysis ...

Journal: :The Journal of nutrition 2008
Thomas Cadoudal Martine Glorian Aurélie Massias Françoise Fouque Claude Forest Chantal Benelli

Glyceroneogenesis is an important metabolic pathway for fatty acid reesterification in adipose tissue, thereby reducing fatty acid release. Glyceroneogenesis and cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C), which is the key enzyme in this pathway, are both regulated by a series of hormones and nutrients, among which all-trans retinoic acid (all-trans RA) is a transcriptional inducer o...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2000
Q Y Zhang D Dunbar L Kaminsky

Retinoic acids have important pleiotropic biological effects and thus the potential for human cytochrome P-450s (CYPs) to mediate retinoic acid synthesis was investigated. We examined the retinoic acid synthetic activity of human cDNA-expressed CYP1A1, 1A2, 1B1, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, 3A4, 3A4+ cytochrome b(5) (b(5)), 3A5, and 4A11, expressed individually in insect cells together w...

Journal: :Nutrients 2021

Vitamin A is a family of derivatives synthesized from carotenoids acquired the diet and can be converted in animals to bioactive forms essential for life. A1 (all-trans-retinol/ATROL) provitamin (all-trans-?,?-carotene/ATBC) are precursors all-trans-retinoic acid acting as ligand retinoic receptors. The contribution ATROL ATBC formation 9-cis-13,14-dihydroretinoic (9CDHRA), only endogenous reti...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 1998
H Chen M R Juchau

The purpose of this study was to investigate whether and to what extent the steric isomerization of retinoic acids in conceptal tissues can be attributed to enzymatic catalysis in addition to thiol-dependent, nonenzymatic catalysis. Conversions of 13-cis-retinoic acid and 9-cis-retinoic acid to all-trans-retinoic acid catalyzed by cell-free preparations of conceptal rat tissues (gestational day...

Journal: :Molecular and cellular biology 1995
L Nagy V A Thomázy G L Shipley L Fésüs W Lamph R A Heyman R A Chandraratna P J Davies

Retinoids induce myeloblastic leukemia (HL-60) cells to differentiate into granulocytes, which subsequently die by apoptosis. Retinoid action is mediated through at least two classes of nuclear receptors: retinoic acid receptors, which bind both all-trans retinoic acid and 9-cis retinoic acid, and retinoid X receptors, which bind only 9-cis retinoic acid. Using receptor-selective synthetic reti...

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