BACKGROUND AND AIMS To explore the molecular mechanisms of miR-886-5p in breast cancer., we examined roles in inhibiting growth and migration of MCF-7 cells. METHODS MiR-886-5p mimics and inhibitors were used to express or inhibit MiR-886-5p, respectively, and MTT and clone formation assays were used to determine the survival and proliferation. Hoechst 33342/ PI double staining was applied to...

Friedreich ataxia (FRDA) is the most common inherited ataxia caused primarily by an intronic GAA.TTC triplet repeat expansion in the frataxin (FXN) gene. FXN RNA and protein levels are reduced in patients leading to progressive gait and limb ataxia, sensory loss, reduced tendon reflexes, dysarthria, absent lower limb reflexes, and loss of position and vibration sense. Neurological manifestation...

Information system development can be considered a collaboration between users and developers. The inability to leverage the localized knowledge embedded in these two stakeholders hinders software development work to achieve high performance. Exploring the ways to counter this difficulty is then critical. This study applies an intellectual capital perspective to address the issues around spanni...

5-Leukotriene pathway inhibitors, Accolate, MK-886, and Zileuton, were evaluated as chemopreventive agents in female strain A mice. The mice were administered by injection vinyl carbamate (2 x 16 mg/kg) to induce lung tumors. Two weeks later, they received in their diet Accolate (270 and 540 mg/kg), MK-886 (30 mg/kg), Zileuton (600 and 1200 mg/kg), or combinations containing the lower concentra...

Chih-Jer Lin 1 and Chun-Ta Chen 2,* 1 Graduate Institute of Automation Technology, National Taipei University of Technology, 1, Section 3, Chung-Hsiao E. Road, Taipei 10608, Taiwan; [email protected] 2 Department of Mechatronic Engineering, National Taiwan Normal University, 162, Section 1, He-ping East Road, Taipei 10610, Taiwan * Correspondence: [email protected]; Tel.: +886-2-7734-3528; Fax...

Tzung-Jiun Tsai1,2 and Ping-I Hsu1,2* 1Department of Internal Medicine, Division of Gastroenterology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan 2National Yang-Ming University, Taipei, Taiwan *Corresponding author: Ping-I Hsu, Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, 386 Ta Chung 1st Road, Kaohsiung 813, Taiwan, Tel: +886-7-...

1389-1286/$ see front matter 2012 Elsevier B.V http://dx.doi.org/10.1016/j.comnet.2012.04.004 ⇑ Corresponding author. Tel.: +886 7381452 73921037. E-mail addresses: [email protected] (C hpds.ee.ncku.edu.tw (Y.-C. Wang), [email protected]. [email protected] (W.-S. Hwang). 1 Tel.: +886 73814526x5533; fax: +886 73921037 2 Tel.: +886 62757575x62359; fax: +886 6234548 A Cross-Layer Ma...