Patterns have emerged as an efficient way to communicate solution proposals. Most software patterns up to now focus on logical design issues. This article presents physical design patterns, that partly employ existing logical patterns. The presented patterns deal with limited physical resources, and framework development. "Advent", combined with the logical "Light'n'Heavy", facilitates online i...

A novel variable rate linear predictive coding (LPC) parameter quantization scheme is proposed in which linear prediction is done by using either the current (forward LPC) or previously decoded (backward LPC) speech blocks. The proposed LPC quantization scheme was integrated into the FS1016 Federal Standard CELP coder. Signi cant LPC bit rate reduction is achieved without compromising the decod...

BACKGROUND Aripiprazole lauroxil (AL) is a long-acting injectable medication approved for the treatment of schizophrenia. Current AL regimens are 441 mg, 662 mg, and 882 mg administered monthly (every 4 weeks [q4wk]), or 882 mg administered every 6 weeks (q6wk). OBJECTIVE We examined the feasibility of a 2-month (every 8 weeks [q8wk]) dosing interval of AL in a phase I open-label pharmacokine...

1. National Institute of Nanotechnology, 11421 Saskatchewan Drive, Edmonton, Canada 2. Department of Physics, University of Alberta, T6G 2E1, Edmonton, Canada 3. ECE, University of Alberta, Canada 4. NIMS, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan 5. Hitachi High-Technologies Corp., 882, Ichige, Hitachinaka-shi, Ibaraki-ken, 312-8504, Japan 6. KLA-Tencore, One Technology Drive, Milpitas, Cal...

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OBJECTIVE This study evaluated the efficacy, safety, and tolerability of aripiprazole lauroxil, a novel long-acting injectable atypical antipsychotic, for the treatment of schizophrenia. METHOD An international multicenter, randomized, double-blind, placebo-controlled trial was conducted between December 2011 and March 2014. Patients (N = 623) aged 18 to 70 years with schizophrenia (DSM-IV-TR...