An anaerobic, quercetin-degrading bacterium was isolated from human feces and identified as Clostridium orbiscindens by comparative 16S rRNA gene sequence analysis. The organism was tested for its ability to transform several flavonoids. The isolated C. orbiscindens strain converted quercetin and taxifolin to 3,4-dihydroxyphenylacetic acid; luteolin and eriodictyol to 3-(3,4-dihydroxyphenyl)pro...

BACKGROUND Test results on the bioavailability of isoflavones in the aglycone or glucoside form in Eastern and Western human subjects are contradictory. OBJECTIVE The objective was to investigate the bioavailability of the soy isoflavones daidzein and genistein in American women with typical American dietary habits after ingestion of the aglycone or glucoside form of isoflavones. DESIGN Fif...

A phytochemical investigation of Allium tuberosum Rottler afforded two new phenylpropane glycosides, named tuberonoid A (1) and B (2), along with four known flavonoids, kaempferol 3-O-β-sophoroside (3), 3-O-β-D-(2-O-feruloyl)-glucosyl-7,4'-di-O-β-D-glucosylkaempferol (4), 3-O-β-sophorosyl-7-O-β-D-(2-O-feruloyl)glucosyl kaempferol (5), kaempferol 3,4'-di-O-β-D-glucoside (6). The identification a...

Objective. MAPK3 activates several nuclear transcription factors, including c-Jun and c-fos, by phosphorylating its downstream cytoplasmic protein, thereby contributing to cell proliferation survival. Different carcinomas’ initiation, progression, cancer metastasis, drug resistance have been associated with overexpression. Given the need for new potent inhibitors, this study aimed explore poten...

To obtain immunomodulating substances from Amazonian medicinal plants, hot water extracts from 21 samples available commercially were tested in terms of mitogenic and colony-stimulating factor (CSF)-inducing activities. Among them, Dalbergia monetaria exhibited the highest CSF-inducing activity. Orobol 8-C-glucoside (OCG-8) and orobol 6-C-glucoside (OCG-6) were isolated from the bark of D. mone...

Three new acylated flavonol glycosides, patuletin 7-O-(6' '-isobutyryl)glucoside (1), patuletin 7-O-[6' '-(2-methylbutyryl)]glucoside (2), and patuletin 7-O-(6' '-isovaleryl)glucoside (3), were isolated from the n-BuOH extract of Inula britannica flowers by bioassay-guided fractionation, together with other known flavonoids. The structures were elucidated by 1D and 2D NMR, FABMS, and other spec...

The antioxidant activity of the aqueous ethanolic extract of Doum leaves, Hyphaene thebaica L. (Palmae), was studied. Data obtained showed that the extract scavenged superoxide anion radicals (IC50=1602 μg/ml) in a dose dependant manner using xanthine/hypoxanthine oxidase assay. Four major flvonoidal compounds were identified by LC/SEI as; Quercetin glucoside, Kaempferol rhamnoglucoside, Dimeth...

Scorzonera species are used in different folk medicines to combat many diseases, including the illnesses connected with inflammation. Previous experiments showed anti-inflammatory activity of Scorzonera extracts in vivo. S. latifolia, S. cana var. jacquiniana, S. tomentosa, S. mollis ssp. szowitsii, S. eriophora, S. incisa, S. cinerea, and S. parviflora extracts were, therefore, evaluated for t...

Lotus plumule, the embryo of seed sacred lotus (Nelumbo nucifera), contains a high accumulation secondary metabolites including flavonoids and possesses important pharmaceutical value. Flavonoid C-glycosides, which accumulate exclusively in have attracted considerable attention recent decades due to their unique chemical structure special bioactivities. As well as mono-C-glycosides, plumule als...

Florida is the main producer of grapefruit (Citrus paradisi Macf.) in the world. Grapefruit provide not only the traditional nutrients (carbohydrates, proteins, vitamins, minerals), but also phytochemicals such as fl avonoids, which are not essential for life, but may provide many health benefi ts. Flavanones are the dominant fl avonoids, and account for about 98% of the total fl avonoids in gr...