نتایج جستجو برای: 733
تعداد نتایج: 1497 فیلتر نتایج به سال:
OBJECTIVE The aim of this study was to evaluate the potential of (18)F-fluorodeoxyglucose-positron emission tomography ((18)F-FDG-PET) for monitoring the therapeutic efficacy of TAK-733, an inhibitor of mitogen-activated protein kinase kinase, in nude rats bearing A549 (human lung carcinoma) xenografts. METHODS TAK-733 was administered orally by gavage to nude xenograft rats for 2 weeks, at d...
Abstract Background Elevated levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) are found in both pre-capillary pulmonary hypertension (PH), including arterial hypertension, PH associated with hypoxia/lung disease and chronic thromboembolic post-capillary left heart disease. We asked the question whether NT-proBNP concentrations differ among these subtypes. Methods Based on right c...
In this paper, we described the application of magnetism-based interaction capture (MAGIC) to find a small-molecule protein target. MAGIC identified the protein ATM as the target of CGK733, a small molecule reportedly isolated by high-throughput screening. A preliminary investigation of the contents of the paper by Korean Advanced Institute of Science and Technology (KAIST) has revealed several...
ABSTRACT We present the results of a coordinated campaign to simultaneously observe M star binary Ross 733 in optical and near-ultraviolet (NUV) with TESS Swift, respectively. observed two flares Swift NUV light curve. One these was decay phase flare that also detected other only NUV. used curve measure white-light rate 733, calculate system an energy 1033 erg once every 1.5 d. our simultaneous...
UNLABELLED Kinase inhibitors are accepted treatment for metastatic melanomas that harbor specific driver mutations in BRAF or KIT, but only 40% to 50% of cases are positive. To uncover other potential targetable mutations, we conducted whole-genome sequencing of a highly aggressive BRAF (V600) and KIT (W557, V559, L576, K642, and D816) wild-type melanoma. Surprisingly, we found a somatic BRAF(L...
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