Understanding about socio-cultural differences in physical activity in children with high and low risk for obesity can help tailor intervention programs in different settings. This study aimed to compare objectively measured physical activity in two-year-olds and their parents, living in Stockholm, Sweden, and Wuhan, China. Data from Early STOPP was used. Children and parents wore an accelerome...

ATR is an attractive target in cancer therapy because it signals replication stress and DNA lesions for repair and to S/G2 checkpoints. Cancer-specific defects in the DNA damage response (DDR) may render cancer cells vulnerable to ATR inhibition alone. We determined the cytotoxicity of the ATR inhibitor VE-821 in isogenically matched cells with DDR imbalance. Cell cycle arrest, DNA damage accum...

Background: Currently available preterm formulas with energy contents of 3350 kJ (800 kcal)/L promote weight and length gain at rates at or above intrauterine growth rates but disproportionately increase total body fat. Objective: The objective of this study was to determine whether fat accretion in formula-fed, very-low-birth-weight (VLBW) infants could be decreased and net protein gain mainta...

Antifungalmycin 702, a new polyene macrolide antibiotic produced by Streptomycespadanus JAU4234, has a broad antifungal activity and may have potential future agricultural and/or clinical applications. However, the mechanism of antifungal action of antifungalmycin 702 remains unknown. Antifungalmycin 702 strongly inhibited mycelial growth and sclerotia formation/germination of Rhizoctonia solan...

Adenosine kinase (AK; EC 2.7.1.20) is a key intracellular enzyme regulating intra-and extracellular concentrations of adenosine (ADO), an endogenous neuromodulator, antinociceptive, and anti-inflammatory autocoid. AK inhibition provides a means of potentiating local tissue concentrations of endogenous ADO, and AK inhibitors may have therapeutic potential as analgesic and anti-inflammatory agent...

Der Inhaber einer im Handelsregister eingetragenen Einzelfirma schloss am 6. März 1996 einen Leasingvertrag über einen Kleinbus für 15 Personen ab und unterzeichnete zugleich mit der Leasinggeberin eine Schuldanerkennung für die Leasingraten. Der Leasingvertrag sowie die Schuldanerkennung wurden einerseits vom Leasingnehmer und andererseits "solidarisch" bzw. als "Solidarschuldner" von dessen T...

Tumor suppressor p53 is a multifunctional transcription factor that regulates diverse cell fates, including apoptosis and autophagy in tumor biology. p53 overexpression enhances the antitumor activity of oncolytic adenoviruses; however, the molecular mechanism of this occurrence remains unclear. We previously developed a tumor-specific replication-competent oncolytic adenovirus, OBP-301, that k...

Tumor suppressor p53 is a multifunctional transcription factor that regulates diverse cell fates, including apoptosis and autophagy in tumor biology. p53 overexpression enhances the antitumor activity of oncolytic adenoviruses; however, the molecular mechanism of this occurrence remains unclear. We previously developed a tumor-specific replication-competent oncolytic adenovirus, OBP-301, that k...

lasting one and two cardiac cycles. Circ Res 35: 702-712, 1974 30. 23. Olsson RA, Gregg DE: Myocardial reactive hyperemia in the unanesthetized dog. Am J Physiol 208: 224-230, 1965 24. Khouri EM, Gregg DE, Lowensohn HS: Flow in the major branches 31. of the left coronary artery during experimental coronary insufficiency in the unanesthetized dog. Circ Res 23: 99-109, 1968 25. Ross G, Mulder DG:...