Lung cancer is one of the malignant tumors with high morbidity and mortality in world. PARP inhibitors have become a new line therapy The mechanism efficacy been well studied some cancers, especially homologous recombination (HR)-deficient ovarian cancer, several cell experiments shown that HR-deficient lung cancers are sensitive to inhibitor. Meanwhile, HHR gene potential biomarker for immunot...

The article presents the results of research, conducted in 2020–2021 commercial hazelnut garden planted 2018 by LLC “Vyazovetsky Sad”, Molodechno district, Minsk region. purpose research is to evaluate growth and development young plants Barcelona Catalan varieties according two schemes placement – 5.0 × 3.5 m (570 plants/ha) 3.0 (666 plants/ha). Biometric parameters plant depending on pattern ...

Purpose: The purpose of the present study was to investigate whether a fluoride modification of the titanium surface would have an effect on bone response after implantation. Materials and Methods: Titanium-oxide–blasted titanium implants with and without fluoride modification were investigated in a rabbit tibia model. Quantitative analysis of surface roughness, biomechanical interlocking, and ...

abstract the quantative and qualitative yield comparison of three cucumber f1 cultivars including' sina, amyral, and negin was evaluated using 3×3×3 factorial experimental design with six replication. three types of pruning treatments were applied; cutting down all branches on main stem (b1), leaving one node and the leaf next to it on all branches (b2), leaving two node and the leaf next to th...

1. Foley RN, Parfrey PS. Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis 1998; 32 [Suppl 3]: S112–S119 2. Cozzolino M, Brancaccio D, Gallieni M, Slatopolsky E. Pathogenesis of vascular calcification in chronic kidney disease. Kidney Int 2005; 68: 429–436 3. Ketteler M, Bongartz P, Westenfeld R et al. Association of low fetuin-A (AHSG) concentrations in ...

Resistance to chemotherapy is the major cause of cancer treatment failure. Insight into the mechanism of action of agents that modulate multidrug resistance (MDR) is instrumental for the design of more effective treatment modalities. Here we show, using KB-V-1 MDR human epidermoid carcinoma cells and [3H]palmitic acid as metabolic tracer, that the MDR modulator SDZ PSC 833 (PSC 833) activates c...