نتایج جستجو برای: 65zn

تعداد نتایج: 134  

Journal: :The Biochemical journal 1979
K T Smith M L Failla R J Cousins

The isolated vascularly perfused rat intestine exhibits an obligatory need for a protein carrier in order to absorb zinc. Therefore this system is ideal for use as a model to identify the plasma carrier during zinc absorption. Affinity chromatography on Blue Sepharose CL-6B was employed to separate the major serum zinc-binding proteins in the portal effluent of the perfused intestine. It was f...

2016
Masayuki Munekane Shinji Motomura Shinichiro Kamino Masashi Ueda Hiromitsu Haba Yutaka Yoshikawa Hiroyuki Yasui Makoto Hiromura Shuichi Enomoto

Various types of zinc (Zn) complexes have been developed as promising antidiabetic agents in recent years. However, the pharmacological action of Zn complex is not elucidated because the biodistribution of the complex in a living organism has not been studied. Nuclear medicine imaging is superior technology for the noninvasive analysis of the temporal distribution of drug candidates in living o...

Journal: :Clinical science 1979
D J Atherton D P Muller P J Aggett J T Harries

1. In a system in vitro, 65Zn accumulation by jejunal mucosal biopsies from patients with acrodermatitis enteropathica was found to be markedly reduced compared with controls. 2. We suggest that defective uptake of zinc by enterocytes is the primary abnormality responsible for the zinc deficiency underlying this disorder.

Journal: :Clinical science 1981
P W Keeling W Ruse J Bull B Hannigan R P Thompson

1. 65Zn was injected intravenously during transjugular liver biopsy and, from simultaneous hepatic and peripheral venous blood samples, hepatointestinal 65Zn extraction was calculated. Hepatic zinc content was measured in biopsy specimens. 2. On the same occasion samples of liver tissue were taken and their zinc content was measured by atomic absorption spectrophotometry. 3. Seven patients with...

Journal: :European Journal of Biochemistry 1970

Journal: :Biological & pharmaceutical bulletin 2017
Masayuki Munekane Masashi Ueda Shinji Motomura Shinichiro Kamino Hiromitsu Haba Yutaka Yoshikawa Hiroyuki Yasui Shuichi Enomoto

Many zinc (Zn) complexes have been developed as promising oral antidiabetic agents. In vitro assays using adipocytes have demonstrated that the coordination structures of Zn complexes affect the uptake of Zn into cells and have insulinomimetic activities, for which moderate stability of Zn complexes is vital. The complexation of Zn plays a major role improving its bioavailability. However, inve...

Journal: :British Journal of Nutrition 1991

Journal: :Journal of Radiation Research 1985

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