The orally available novel small molecules PF06463922 [(10R)-7-amino12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8, 4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3carbonitrile] and PF06471402 [(10R)-7-amino-12-fluoro-2,10,16-trimethyl15-oxo-10,15,16,17-tetrahydro-2H-8,4-(azeno)pyrazolo[4,3-h][2,5,11] benzoxadiazacyclo-tetradecine-3-carbonitrile] are second-gener...