We investigatedthe transformingactivityofthe ret proto-oncogenewith a mutation in cysteine 609, 611, 618, 620, 630, or 634 detected in patients with multiple endocrine neoplasia type 2A (MEN 2A), familial meduilary thyroid carcinoma (FMTC), or Hirschsprung's disease. Of these cysteine mutations, codon 634 mutations are known to he correlated with the development of MEN 2A, whereas codon 609, 61...

a Department of Biological Sciences, Pusan National University, Busan 609–735, South Korea b Institute of Environmental Technology & Industry, Pusan National University, Busan 609–735, South Korea c Department of Environmental Education, Sunchon National University, Suncheon, Jeonnam 540-742, South Korea d Department of Environmental Science and Engineering, Kyung-Hee University, Yongin, Gyeong...

Metabolic enzymes involved in benzene activation or detoxification, including NAD(P)H, quinone oxidoreductase 1 (NQO1), cytochrome P450 2E1 (CYP2E1), myeloperoxidase (MPO), glutathione-S-transferase mu-1 (GSTM1), and glutathione-S-transferase theta-1 (GSTT1), were studied for their roles in human susceptibility to benzene poisoning. The potential interactions of these metabolic enzymes with lif...

We studied the pharmacological characteristics of HSR-609 (3-[4-(8-fluoro-5,11-dihydrobenz[b]oxepino[4,3-b]pyridin-11- ylidene)- piperidino]propionic acid dihydrate), a novel amphoteric antiallergic agent, on the central nervous system (CNS). Its selectivity for the histamine H1-receptor and its ability to penetrate into the CNS were compared with those of typical antiallergic agents and the no...

پیرو یافتن تک‌یاخته­ی Hepatozoon canis و نماتود Cercopithifilaria bainae در سگ­های ایران، این مطالعه با هدف تشخیص ناقلین بالقوه­ی دو انگل میان کنه­های جمع­آوری شده از ۵ استان ایران انجام شد. مهر ماه 1397 تا خرداد 1401 تعداد 222 قلاده سگ صاحبدار 541 ولگرد استان­های­ همدان (305 قلاده)، کرمانشاه (227 یزد (80 خوزستان (71 قلاده) مازندران جهت آلودگی به کنه­ مورد بررسی قرار گرفتند. جمع آوری (3339 عدد)...

Young Mi Kwon, Jaewon Lee, Hyung Suk Baik, Byung Pal Yu and Hae Young Chung* College of Pharmacy, Pusan National University, Busan 609-735, Korea MRC for Ischemic Tissue Regeneration, College of Medicine, Pusan National University, Busan 602-739, Korea 3 Genetic Engineering Research Institute, Pusan National University, Busan, 609-735, Korea Department of Physiology, The University of Texas Hea...

Sera from virtually all individuals infected with human immunodeficiency virus contain antibodies against the viral envelope glycoproteins. By using a series of synthetic peptide antigens, we identified an immunodominant domain at amino acid position 598-609 of gp41. The minimal essential epitope is a 7-amino-acid sequence (amino acids 603-609) containing two cysteine residues. Both cysteine re...