نتایج جستجو برای: 60 hsp60

تعداد نتایج: 301710  

Journal: :Infection and immunity 2004
Liangxuan Zhang Steven Pelech Veli-Jukka Uitto

Our previous studies showed that bacterial heat shock protein 60 (hsp60) induces cultured epithelial cell proliferation within 24 h. Here we investigated the long-term effects of heat shock protein 60 isolated from Actinobacillus actinomycetemcomitans on skin keratinocyte (HaCaT cell line) viability and the cell signaling involved. Prolonged incubation in the presence of hsp60 increased the rat...

Journal: :PLoS ONE 2008
Francisco J. Quintana Avishai Mimran Pnina Carmi Felix Mor Irun R. Cohen

The 60 kDa heat shock protein (HSP60) has been reported to influence T-cell responses in two ways: as a ligand of toll-like receptor 2 signalling and as an antigen. Here we describe a new mechanism of T-cell immuno-regulation focused on HSP60: HSP60 is up-regulated and presented by activated T cells (HSP60 is an ergotope) to regulatory (anti-ergotypic) T cells. Presentation of HSP60 by activate...

2014
Xiao-shan Li Qing Xu Xiang-yang Fu Wei-sheng Luo

BACKGROUND Heat shock protein 60 (HSP60) is a chaperonin with essential functions for cell physiology and survival, and its expression correlates with prognosis in a number of malignancies. The aim of this study is to determine the relationship of HSP60 status with clinicopathological parameters and prognosis in gastric cancer. METHODS The levels of HSP60 and matrix metallopeptidase 9 (MMP-9)...

Journal: :Journal of immunology 2005
Alexandra Zanin-Zhorov Rafael Bruck Guy Tal Shirly Oren Hussein Aeed Rami Hershkoviz Irun R Cohen Ofer Lider

Extracellular heat shock protein 60 (HSP60) has been considered a proinflammatory danger signal. Yet, HSP60 can also down-regulate experimental immune arthritis and diabetes models by specific inhibition of Th1-like responses. We now report that HSP60 in vitro differentially modulates the expression of Th1/Th2 transcription factors in human T cells: HSP60 down-regulates T-bet, NF-kappaB, and NF...

2016
Joshua Juwono Ryan D Martinus

The focus of this review is to summarise the known relationships between the expression of heat shock protein 60 (Hsp60) and its association with the pathogenesis of Type 1 and Type 2 diabetes mellitus. Hsp60 is a mitochondrial stress protein that is induced by mitochondrial impairment. It is known to be secreted from a number of cell types and circulating levels have been documented in both Ty...

2012
Tina Märker Henrike Sell Pia Zilleßen Anja Glöde Jennifer Kriebel D. Margriet Ouwens Piet Pattyn Johannes Ruige Susanne Famulla Michael Roden Jürgen Eckel Christiane Habich

The stress protein heat shock protein 60 (Hsp60) induces secretion of proinflammatory mediators from murine adipocytes. This study aimed to study Hsp60 as a mediator of adipose tissue inflammation and skeletal muscle cell (SkMC) insulin sensitivity and to quantify plasma Hsp60 concentrations in lean and obese individuals. Regulation of Hsp60 release and Hsp60-induced cytokine secretion and sign...

Journal: :Infection and immunity 1997
Y Yi X Yang R C Brunham

The immunopathologic sequelae of chlamydial infection are correlated with immune responses to the Chlamydia trachomatis heat shock protein 60 (hsp60). One pathogenic mechanism that may explain this association is the induction of autoimmune responses to self hsp60, since these two proteins share a high degree of amino acid sequence identity. To investigate the conditions under which autoimmune ...

Journal: :Journal of immunology 2005
Christiane Habich Karina Kempe Ruurd van der Zee Robert Rümenapf Hidehiko Akiyama Hubert Kolb Volker Burkart

Human heat shock protein 60 (HSP60) has been shown to bind to the surface of innate immune cells and to elicit a proinflammatory response. In this study we demonstrate that the macrophage stimulatory property of recombinant human HSP60 is tightly linked to the HSP60 molecule and is lost after protease treatment. However, inhibition of macrophage stimulation was reached by the LPS-binding peptid...

Journal: :Circulation 2008
Xiaomin Zhang Mei'an He Longxian Cheng Ying Chen Li Zhou Hesong Zeng A Graham Pockley Frank B Hu Tangchun Wu

BACKGROUND Although heat shock protein 60 (Hsp60) is implicated in the pathogenesis of atherosclerosis, its role in coronary heart disease (CHD) is uncertain. This study explored the influence of circulating Hsp60 on CHD in a large case-control study, as well as the impact of acute myocardial infarction on Hsp60 levels in a prospective study. METHODS AND RESULTS Plasma Hsp60 and anti-Hsp60 an...

Journal: :Journal of immunology 2003
Stefanie B Flohé Jutta Brüggemann Sven Lendemans Marina Nikulina Guido Meierhoff Sascha Flohé Hubert Kolb

Heat shock protein (HSP) 60 nonspecifically activates cells of the innate immune system. In the present study, we characterized the effects of human HSP60 maturation, cytokine release, and T cell-activating capacity of bone marrow-derived dendritic cells (DC). Furthermore, we analyzed HSP60-induced signal transduction in DC. HSP60 strongly stimulated DC for maturation and release of TNF-alpha, ...

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