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BACKGROUND Both the Department of Defense (DoD) and the Department of Health and Human Services (DHHS) currently require two confirmation tests to verify use of heroin, one test for total morphine and a separate test for 6-acetylmorphine (6-AM). Our aim was to determine appropriate free-codeine, free-morphine, and 6-AM cutoff concentrations that could be substituted for total-morphine, total-co...

PurposeHeartCare is a non-invasive method of surveillance for cardiac allograft rejection comprised gene expression profiling (AlloMap, AM) and donor derived cell-free DNA (AlloSure-Heart, AS). AM scores inform immune quiescence whereas AS reflects presence tissue injury.MethodsSurveillance HeartCare Outcomes Registry (SHORE) multicenter, observational registry assessing the clinical utility AS...

OBJECTIVE The demonstration that cardiovascular mortality follows a circadian rhythm led us to verify whether patients dying at the intensive unit care (ICU) and at the non-intensive unit care (non-ICU) follow that rhythm. METHODS All hospital's deaths occurring between January 1, 2006 and July 31, 2010 were analyzed. The circadian pattern of the time of death was analyzed in twelve 2 hour in...