نتایج جستجو برای: 5ht1a

تعداد نتایج: 161  

In the present study, we have investigated the effects of silymarine on depression and the possible role of serotonergic system in these effects. The rats were anesthetized intraperitoneally with ketamine hydrochloride and placed in a Stoelting stereotaxic instrument. A stainless steel guide cannula (22-gauge) was implanted in the third ventricular region. The third ventricular region was infus...

Journal: :Psychiatria Danubina 2012
Hans Rittmannsberger Regina Werl

Serotonin syndrome (SS) is an adverse drug reaction induced by hyperstimulation of postsynaptic serotonin receptors (Boyer & Shannon 2005). The syndrome includes psychiatric symptoms (unrest, disturbed sleep, elevated mood, confusion, semicoma or coma, ...), neurological symptoms (myoclonus, tremors, hyperreflexia, impaired coordination, ...), and autonomic symptoms (fever, hyperhidrosis, diarr...

2011
Aleksandar Chanachev Nicolas Ansermot Séverine Crettol Wavre Ute Nowotka Maria-Eleni Stamatopoulou Philippe Conus Chin B. Eap

There exist many case reports and studies on the antipsychotic augmentation by aripirazole in partial responders to clozapine, the most seem to be finding a slight difference in the PANSS and CGI scores after the aripirazole addition. The results of our report are compatible with those of other studies but, we have found a considerable antianxiety action in both of the cases. The 5HT1A agonism ...

Journal: :The Journal of neuropsychiatry and clinical neurosciences 2010
Matteo Pardini Silvia Guida Leonardo Emberti Gialloreti

To the Editor: Coprophagia (ingestion of feces) is considered a variant of pica that can generate intense emotional reactions in those exposed to it. To date, its psychopathological bases remain ill-understood, and clear evidence for its treatment is lacking. We report a case of coprophagia occurring in a young man with autistic spectrum disorder that subsided after a short treatment with aripi...

Journal: :Physiology & behavior 2005
Irina Knyshevski Lesley A Ricci Thomas E McCann Richard H Melloni

Hamsters repeatedly exposed to cocaine throughout adolescence display highly escalated offensive aggression compared to saline-treated littermates. Recently, we have shown that serotonin neural signaling and development play an important role in adolescent cocaine-induced offensive aggression. This study examined whether the adolescent cocaine-induced aggressive response was modulated by seroto...

Journal: :Brain Research 2016
Bruna Balbino de Paula Christie Ramos Andrade Leite-Panissi

The tonic immobility (TI) response is an innate fear behavior associated with intensely dangerous situations, exhibited by many species of invertebrate and vertebrate animals. In humans, it is possible that TI predicts the severity of posttraumatic stress disorder symptoms. This behavioral response is initiated and sustained by the stimulation of various groups of neurons distributed in the tel...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1993
N Dascal N F Lim W Schreibmayer W Wang N Davidson H A Lester

Injection of rat atrial RNA into Xenopus oocytes resulted in the expression of guanine nucleotide binding (G) protein-activated K+ channel. Current through the channel could be activated by acetylcholine or, if RNA encoding a neuronal 5HT1A receptor was coinjected with atrial RNA, by serotonin (5HT). A 5HT-evoked current (I5HT) was observed in oocytes injected with ventricle RNA fractions (of 2...

2006
Theodore A. Slotkin Charlotte A. Tate Ian T. Ryde Edward D. Levin Frederic J. Seidler

BACKGROUND In the developing brain, serotonin (5HT) systems are among the most sensitive to disruption by organophosphates. OBJECTIVES We exposed neonatal rats to daily doses of diazinon or parathion on postnatal days (PND)1-4 and evaluated 5HT receptors and the 5HT transporter in brainstem and forebrain on PND5, focusing on doses of each agent below the maximum tolerated dose and spanning th...

2017
Mariana G Fronza Lucimar M Pinto Brod Angela Maria Casaril Manoela Sacramento Diego Alves Lucielli Savegnago

A series of phenylselanyl-1H-1,2,3-triazole-4-carbonitriles with different substituents were screened for their binding affinity with serotonin transporter (SERT) and dopamine transporter (DAT) by docking molecular. 5-(4methoxyphenyl)-1-(2-(phenylselanyl)phenyl)-1H-1,2,3-triazole-4-carbonitrile (SeTACN) exhibited the best conformation with SERT even higher than fluoxetine and serotonin, suggest...

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