The gene coding for Pseudomonas aeruginosa cytochrome c-551 was expressed in Pseudomonas putida under aerobic conditions, using two different expression vectors; the more efficient proved to be pNM185, induced by m-toluate. Mature holo-(cytochrome c-551) was produced in high yield by this expression system, and was purified to homogeneity. Comparison of the recombinant wild-type protein with th...

Jaundice is a common neonatal problem. Since bilirubin is potentially toxic to the central nervous system, early detection and appropriate management of neonatal jaundice (NNJ) is of paramount importance, especially when bilirubin even in physiological ranges may cause permanent neuronal injury. We, therefore, undertook the present study to assess the incidence, severity, causes and therapeutic...

PURPOSE OT-551 (1-hydroxy-4-cyclopropanecarbonyloxy-2,2,6,6-tetramethylpiperidine hydrochloride), a TEMPOL-H (OT-674) derivative, is a new catalytic antioxidant. In the present study, the efficacy of OT-551 and OT-674 in retinal neuroprotection was tested in a model of light-induced photoreceptor degeneration. METHODS Albino rats were intraperitoneally injected with OT-551, OT-674, or water, ...

The isolation of cytochrome c peroxidase, cytochrome c4, cytochrome c-551 and azurin from Pseudomonas dentrificans is described. The peroxidase has a molecular weight of 63,000 and an isoelectric point of 5.6. Its absorption spectrum suggests that it contains two haem c groups/molecule. Preliminary steady-state kinetic data are reported with cytochromes c-551 and c4 and azurin as the second sub...

*Contact Information: 12 13 Alexander Gail, Ph.D. 14 Bernstein Center for Computational Neuroscience, 15 German Primate Center 16 Kellnerweg 4, 37077, Göttingen, Germany 17 Tel +49(0)551 3851 358 18 Fax +49(0)551 3851 452 19 E-mail: [email protected] 20 21 Running Head: 22 Synchronization in PRR and PMd 23 24

Background MEDI-551, an IgG1k antibody-dependent cellular cytotoxicity (ADCC) enhanced anti-CD19 monoclonal antibody (mAb), has a single-agent response rate of 24% (12% with complete remission [CR]) in heavily pretreated patients with diffuse large B cell lymphoma (DLBCL). MEDI0680 (AMP-514) a humanized IgG4 mAb against PD-1, blocks inhibitory PD-1 receptors (PD-L1) on T cells to augment immune...

Prof. Dr. med. Uwe Groß University Medical Center Institute for Medical Microbiology Kreuzbergring 57, D-37075 Goettingen, Germany Tel:+49-551-395801/5806 Fax: +49-551-39 5861 [email protected] Copyright © 2011, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Clin. Microbiol. doi:10.1128/JCM.00464-11 JCM Accepts, published online ahead of print on ...

PURPOSE To investigate the prevalence of Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Mycoplasma genitalium (MG), and Ureaplasma urealyticum (UU) in first-voided urine samples and to determine the factors associated with positivity for sexually transmissible microorganisms in healthy, middle-aged Korean men. MATERIALS AND METHODS Five hundred fifty-one men who came to the hospital ...

Address for correspondence: Prof. Dr. Wolfgang Wuttke, Department of Endocrinology, University Medical Center Goettingen, Georg-AugustUniversity, Robert-Koch-Strasse 40, D-37099 Goettingen/ Germany, Tel.: +49-551-396714, Fax: +49-551-396518, E-mail: [email protected] Received 10-11-09, Revised 12-12-09, Accepted 2 -12-09