نتایج جستجو برای: 527
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Postmenopausal Genital Tuberculosis W. H. Roberts .......................... 526 Footballer's Migraine R. N. Lucas, D.P.M ..................... 526 Recurrent Urinary Infections in a Girl R. H. Jackson, F.R.C.P., and A. Smith, F.R.C.G.P ............................... 526 Recurrent Urinary Infections P. Dure-Smith, M.D., F.F.R ............... 527 Depressive Illness and Aggression in Belfast H. A...
BACKGROUND AND PURPOSE The Kaposi sarcoma (KS)-associated herpesvirus GPCR (vGPCR) is a key molecule in the pathogenesis of KS, where it increases NF-κB gene expression and activates the NF-κB pathway. We investigated whether the less calcemic vitamin D analogue TX 527 inhibited the proliferation of endothelial cells transformed by vGPCR by modulation of the NF-κB pathway. EXPERIMENTAL APPROA...
The biological activity of two novel 14-epi-analogues of 1,25(OH)2D3, 19-nor-14-epi-23-yne-1,25(OH)2D3 (TX 522) and 19-nor-14,20-bisepi-23-yne-1,25(OH)2D3 (TX 527), is described. Both analogues were at least 10 times more potent than 1,25(OH)2D3 in inhibiting in vitro cell proliferation and had much lower in vivo calcemic effects than 1,25(OH)2D3. Treatment with 1,25(OH)2D3, TX 522, or TX 527 i...
(51) Int. Cl. B03C1102 (2006.01) C12M 1/00 (2006.01) (52) U.S. Cl. USPC ................... 210/222; 252/62.51 R; 422/68.1; 422/502; 422/504; 422/527; 435/287.2; 435/308.1; 436/526; 436/806 (58) Field of Classification Search USPC ........... 210/222; 252/62.51 R; 422/68.1, 502, 422/504, 527; 435/287.2, 308.1; 436/526, 436/806 See application file for complete search history. (1o) Patent No.: U...
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