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I am delighted to present this issue of the Journal of Cardiovascular Disease Research (JCDR). The JCDR is proud to enter 2012 in a strong position. Readers may be aware that Wolters Kluwer Health (Philadelphia, PA) acquired Medknow and thus became the publisher of JCDR. Wolters Kluwer Health is a leading global provider of information and business intelligence for physicians, nurses, students ...
Ubiquitin (Ub) is a highly conserved protein composed of 76 aa that can be covalently linked to a lysine residue of a target protein. Attachment of a single Ub monomer to one or several lysines of a protein (monoor multimonoubiquitylation, respectively) is notably involved in endocytosis and the regulation of histones (Hicke, 2001). Ub itself possesses several lysines that can be used for the a...
efl/esl textbooks have been regarded as essential language teaching materials with which the learners spend about 70 up to 90 percent of their class time. the important role they play and their vast use make them not only influential in learning the language but also in shaping values and attitudes. put it another way, textbooks socialize learners using their contents (i.e. texts, illustrations...
the rationale behind the present study is that particular learning strategies produce more effective results when applied together. the present study tried to investigate the efficiency of the semantic-context strategy alone with a technique called, keyword method. to clarify the point, the current study seeked to find answer to the following question: are the keyword and semantic-context metho...
Département de Santé Publique, Unité de Recherche sur les Politiques et Systèmes de Santé, Centre Muraz, 2054 Avenue Mamadou Konaté, 01 BP 390 Bobo-Dioulasso, Burkina Faso Agence de Formation, de Recherche et d’Expertise en Santé pour l’Afrique (AFRICSanté), 773 Rue Guillaume Ouédraogo 01 BP 298 Bobo-Dioulasso, Burkina Faso Department of Community Medicine, University of Oslo, Post Box 1130 Bli...
Memories maintained in patterns of synaptic connectivity are rapidly overwritten and destroyed by ongoing plasticity related to the storage of new memories. Short memory lifetimes arise from the bounds that must be imposed on synaptic efficacy in any realistic model. We explored whether memory performance can be improved by allowing synapses to traverse a large number of states before reaching ...
We developed a hybrid method for predicting plasma concentration-time curves in humans by integrating species differences in in vitro intrinsic clearance (CLint) into the Dedrick approach based on the allometry concept. With prediction of clearance (CL) by allometric scaling, taking in vitro CLint into consideration improved the accuracy and reduced the average fold error from 2.72 to 1.99. Wit...
The ocean's interior is Earth's largest biome. Recently, cultivationindependent ribosomal RNA gene surveys have indicated a potential importance for archaea in the subsurface ocean. But quantitative data on the abundance of speci®c microbial groups in the deep sea are lacking. Here we report a year-long study of the abundance of two speci®c archaeal groups (pelagic euryarchaeota and pelagic cre...
It is commonly believed that only T lymphocytes and B lymphocytes expressing recombination-dependent antigen-specific receptors mediate contact hypersensitivity responses to haptens. Here we found that mice devoid of T cells and B cells demonstrated substantial contact hypersensitivity responses to 2,4-dinitrofluorobenzene and oxazolone. Those responses were adaptive in nature, as they persiste...
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