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New anthracycline antibiotics 3'-O-demethyl mutactimycin (3) and 4-O,3'-O-didemethyl mutactimycin (4) were isolated from two actinomycetes strains, Nocardia transvalensis and Streptomyces sp. GW 60/1571. The chemical structures were elucidated by mass spectrometry and NMR spectroscopy. Antibiotic 3 displayed moderate antimicrobial activity against Gram-positive bacteria and cytotoxicity against...
An outcome of the intricate K+ regulation in the cochlear duct is the endocochlear potential (EP), approximately 80 mV, the "battery" that runs hair-cell transduction; however, the detailed molecular mechanisms for the generation of the EP remain unclear. We provide strong evidence indicating that the intermediate cells (ICs) of the stria vascularis (StV) express outward K+ current that rectifi...
Polarization-transfer components for He(~e, e~ p)H are computed within the relativistic multiplescattering Glauber approximation (RMSGA). The RMSGA framework adopts relativistic singleparticle wave functions and electron-nucleon couplings. The predictions with free and various parametrizations for the medium-modified electromagnetic form factors are compared to the world data. In conventional n...
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