Hepatotoxic effect of 5-Fluourouracil (5-FU) can deprive cancer patients of maximum therapeutic benefits. Aim: This study assessed the ability of selenium (Se) to protect against hepatotoxicity induced by 5-FU in rats. Forty adult albino rats were groups and used. Rats in group A (control) were treated intraperitoneally (ip) with 0.2ml of normal saline daily for 5 days. Rats in groups B1-B3 wer...

several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-fu related toxicity. the aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-fu in rabbits, mice and dogs. it was further aimed to determine its route related toxicity in rabbits.    plasma concentration of both 5-fu and its metabolite 5-f...

5‐fluorouracil (5-FU), a pyrimidine analogue anticarcinogenic agent, is widely used in the solid tumors treatment. Use of 5-FU causes cardiotoxicity. Our aim this study investigations effects Quercetin and Rutin on ECG parameters 5-FU-induced cardiotoxicity rats. In present male Rats were divided randomly to eight group. The control group was given intragastric corn oil for 14 days. rats ig day...

Two common single nucleotide polymorphisms (SNPs) of the human TLR4 gene, namely Asp299Gly (D299G) and Thr399Ile (T399I), have been shown to impair the ability of certain individuals to respond properly to TLR4 ligands. 5-Fluorouracil (5-FU) is widely used for the treatment of patients with advanced colon cancers. The present study examined the impact of two common polymorphisms of the TLR4 gen...

two common single nucleotide polymorphisms (snps) of the human tlr4 gene, namely asp299gly (d299g) and thr399ile (t399i), have been shown to impair the ability of certain individuals to respond properly to tlr4 ligands. 5-fluorouracil (5-fu) is widely used for the treatment of patients with advanced colon cancers. the present study examined the impact of two common polymorphisms of the tlr4 gen...