Abstract Actinic keratoses (AK) are common in immunocompromised patients and associated with increased risk of cutaneous squamous cell carcinoma (cSCC). The current standard care is 5-fluorouracil cream 5% (5-FU) monotherapy for 4 weeks. In recent years, 5-FU calcipotriol ointment (5-FU-Cal) combination AK therapy 4–6 days has emerged as potentially more effective better tolerated, although the...

5-Fluorouracil (5-FU) cream was compared with podophyllin 25 percent in alcohol for treating genital and urethral condylomata acuminata. The cure rate after four weeks was found to be 6 of 18 patients treated with 5-FU and 10 of 19 treated with podophyllin. By changing the treatment for those not cured, warts regressed after four weeks in four more patients in each group. Patients were followe...

Carac (5-fluorouracil 0.5% cream, Aventis Pharma) was approved by the US FDA in October 2000, for the treatment of multiple actinic or solar keratoses involving the face and anterior scalp. The cream should be applied in a thin film once daily to the skin where actinic keratoses (AKs) are present. When it is applied for 1, 2, or 4 weeks, it is significantly more effective than a vehicle in the ...

Hypertrophic scars exhibit a higher prevalence within groups with darker skin tones. The Vancouver Scar Scale, patient and observer scar evaluation scale, high resolution ultrasound, Modified Scales, ultra-high frequency tonometry, multiphoton microscopy laser Doppler imaging are considered to be optimal tools for measurement of scar. therapeutic modalities employed the hypertrophic management ...

BACKGROUND Various therapeutic options, including surgery, electrocautery, cryotherapy, 5-fluorouracil treatment, laser therapy, radiotherapy, photodynamic therapy, and interferon-α/γ injection, have been employed to treat vulvar intraepithelial neoplasia (VIN) with varying degrees of success. To truly cure VIN, human papillomavirus elimination is considered important. OBJECTIVE To investigat...

Report of a Case Awoman in her 50s presentedwith an 8-year history of an annular plaque in the left perioral area. Physical examination showeda thick hyperkeratotic annular plaque with elevated edges and an atrophic center (Figure 1).Histopathologic examinationof the lesion revealedacornoid lamella, anunderlyingepidermisdevoidof agranular layer, and a lymphocytic infiltration in the upper dermi...

The issue of third-party reimbursement also came up. “We hope the guidelines will help with reimbursement with some of these therapies by becoming standard practice,” Denlinger said. “But we don’t yet know.” Similarly, Philippe Spiess, M.D., genitourinary oncologist at H. Lee Moffitt Cancer Center in Tampa, Fla., and a member of NCCN’s bladder/penile cancer panel, said that uncertainty surround...