In N-methyl-N-nitrosourea (MNU)-induced colon cancer modeling in rats, it was aimed to evaluate the regressive effect of grayanotoxin-rich Turkish mad honey and 5-fluorouracil (5-FU), separately together. Study groups were control group (CG), (CCG), 5-Flourouracil (FUG), (HG), 5-FU combined (FU-HG). WBC, lymphocyte, eosinophil, basophil, serum LDH, TOS, total protein values determined rats CCG ...

N-nicotinyl-2-(5-fluorouracil-1-yl)-D,L-glycine (NFG) and N-isonicotinyl-2-(5-fluorouracil-1-yl)-D,L-glycine (INFG) were synthesized as colon-specific prodrugs of 5-fluorouracil (5-FU). As N-aromatic acyl amides of glycine, they are expected to be stable in the upper intestine and delivered to the colon as an intact form if they are nonabsorbable. Microbial hydrolysis of amide bond in the colon...

Background: Cyclophosphamide (CPA) is a drug with wide spectrum of clinical uses. It commonly used as anticancer and immuno suppressant agent. induces hyperlipidemia myocardium damage. 5-FU widely in the treatment range cancers. combination other chemotherapeutic agents improves response rates survival breast head neck Objectives: The present study aimed to evaluate antidyslipidemic effect 5-fl...

Background: Cyclophosphamide (CPA) induces acute inflammation of the urinary bladder, renal damage, and liver thereby limiting its therapeutic use. Objectives: The present study aimed to evaluate hepatorenal toxicity induced by cyclophosphamide amelioration 5-fluorouracil in male albino rats. Materials Methods: Twenty-eight adult rats were grouped randomly into four groups (n=5 for each group)....

5-Fluorouracil (5-FU) based chemotherapy has been commonly used to treat metastatic or advanced colon cancer as an adjuvant chemotherapy. Although the side effects of 5-FU such as gastrointestinal problems and neutropenia and thrombocytopenia are common, not many cases of 5-FU related encephalopathy are reported. Hyperammonemic encephalopathy is a rare central nervous system toxicity following ...