نتایج جستجو برای: 5 dimethoxytrityl group
تعداد نتایج: 2036781 فیلتر نتایج به سال:
A number of 5'-O-(4,4'-dimethoxytrityl)thymidine N,N-diisopropylamino phosphoramidites protected at P(III) with derivatives of 2-benzamidoethanol were synthesized and incorporated into synthetic oligonucleotides. Depending on substitution patterns at the alkyl chain, amido group, and phenyl ring, the time required for removal of these protecting groups using concentrated ammonium hydroxide vari...
Results from a number of recent studies suggest that amino acid insertion mutations may provide an important alternative to substitution mutations for modifying protein structures and functional activities. To facilitate the use of single-amino acid insertions, we have developed a general strategy for inducing random, in-phase codon insertions across a defined segment of a cloned gene. In brief...
The nucleoside 2'-deoxyzebularine (K) was incorporated into the self-complementary dodecamer 5'-CGTACGKGTACG-3' by solid-phase 2-cyanoethylphosphoramidite chemistry using dimethoxytrityl (DMT) as the 5'-hydroxyl protecting group. Standard synthesis cycles using trichloroacetic acid and short ammonia treatment (50 degrees C for 30 min) were found to be the optimal conditions to obtain the desire...
هدف از انجام این تحقیق ارزیابی اثر تکرارهای مکرر hcg بر روی ویژگیهای جسم زرد و فولیکولهای موجود بر سطح تخمدان و غلظت پروژسترون میش های سنجابی سوپراووله شده با ecg می باشد. تعداد 40 راس میش سنجابی بوسیله اسفنج آغشته به پروژسترون به مدت 12 روز جهت همزمان سازی فحلی مورد درمان قرار گرفتند . سوپراوولاسیون در این دامها بوسیله ecg، 2روز قبل از خروج اسفنج القاء شد. در روز خروج اسفنج (روز صفر) میش ها بص...
We describe the preparation of several types of porous silicon (pSi) microparticles as supports for the solid-phase synthesis of oligonucleotides. The first of these supports facilitates oligonucleotide release from the nanostructured support during the oligonucleotide deprotection step, while the second type of support is able to withstand the cleavage and deprotection of the oligonucleotides ...
2-Am ino-5-nitro-6-(r-D -ribityl)am ino-4(3H )-pyrim idinone (6a) was converted to the dimethoxytrityl derivative, which was subsequently acetylated. The trityl residue was then rem oved, and the compound was phosphorylated by the cyanoethyl method. Rem oval of the protecting groups yielded 2-am ino-5-nitro-6-(l'-D-ribityl)am inopyrim idinone 5'-phosphate (11a). Catalytic hy drogenation yielde...
Based on our recent studies of RNA cleavage by oligonucleotide-terpyridine.Cu(II) complex 5'- and/or 3'-conjugates, we designed 2'-O-methyloligonucleotides with two terpyridine-attached nucleosides at contiguous internal sites. To connect the 2'-terpyridine-modified uridine residue at the 5'-side to the 5'-O-terpyridyl nucleoside residue at the 3'-side, a dimethoxytrityl derivative of 5-hydroxy...
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