PX-478 is a new agent known to inhibit the hypoxia-responsive transcription factor, HIF-1alpha, in experimental tumors. The current study was undertaken in preparation for clinical trials to determine which noninvasive imaging endpoint(s) is sensitive to this drug's actions. Dynamic contrast-enhanced (DCE) and diffusion-weighted (DW) magnetic resonance imaging (MRI) were used to monitor acute e...

1 School of Mechanical Engineering, Kumoh National Institute of Technology, Kumi, Kyungbuk, South Korea 2 School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA 3 Center for Assistive Technology and Environmental Access (CATEA), Georgia Institute of Technology, Atlanta, Georgia, USA # Corresponding Author / E-mail: [email protected]; Tel: +82-54-478-7344; Fax:...

The process of biodegradation in lingo-cellulosic materials is critically relevant to biospheric carbon. The study of this natural process has largely involved laboratory investigations, focused primarily on the biodegradation and recycling of agricultural by-products, generally using basidiomycetes species. In order to collect super white rot fungi and evaluate its ability to degrade lingo-cel...

⁎ Corresponding authors. Savov is to be contac Environment, University of Leeds, Leeds LS2 9JT, Unite 5199; fax: +44 133 343 5259. Leeman, Earth Scien Foundation, Arlington, VA 22230, U.S.A. Tel.: +1 703 29 E-mail addresses: [email protected] (I.P. Savov (W.P. Leeman), [email protected] (C.-T.A. Lee), shirey@dtm 1 Tel.: +1 713 348 5084; fax: +1 713 348 5214. 2 Tel.: +1 202 478 8473; fax: +1 ...

BHARATHRAM GANAPATHISUBRAMANI, ELLEN K. LONGMIRE and IVAN MARUSIC Journal of Fluid Mechanics / Volume 478 / March 2003, pp 35 ­ 46 DOI: 10.1017/S0022112002003270, Published online: 17 March 2003 Link to this article: http://journals.cambridge.org/abstract_S0022112002003270 How to cite this article: BHARATHRAM GANAPATHISUBRAMANI, ELLEN K. LONGMIRE and IVAN MARUSIC (2003). Characteristics of vort...

Purpose. To validate the function of autophagy with the regulation of hypoxia inhibitor-induced glycosylation in oral squamous cell carcinoma cell. Methods. Human Tca8113 cell line was used to detect autophagy and glycosylation related protein expression by western blotting and immunofluorescence with HIF-1α inhibitor. Short interfering RNA (siRNA) transfection blocked human ATG12 and ATG1. Res...

Pancreatic ductal adenocarcinoma (PDAC) is the worst prognoses among all the malignancies. Now, gemcitabine (Gem) is the first line chemotherapeutic drug for advanced pancreatic cancer. However, Gem is usually ineffective to the PDAC because of high degree of drug resistance. Hypoxia and immune suppressive milieu are the best-described hallmarks of PDAC; therefore, we investigated the impact of...