The effect of consumers’ compliance with nutritional recommendations is uncertain because of potentially complex substitutions. To lift this uncertainty, we adapt a model of consumer behaviour under rationing to the case of linear nutritional constraints. Dietary adjustments are thus derived from information on consumer preferences, consumption levels, and nutritional contents of foods. A calib...

The protein kinase B (PKB)/Akt family of serine kinases is rapidly activated following agonist-induced stimulation of phosphoinositide 3-kinase (PI3K). To probe the molecular events important for the activation process, we employed two distinct models of posttranslational inducible activation and membrane recruitment. PKB induction requires phosphorylation of two critical residues, threonine 30...

The spectral characteristics of 1,2,3,8-tetrahydro-1,2,3,3,8-pentamethyl-5-(trifluoromethyl)-7H–pyrrolo[3,2-g]quinolin-7one (LD-473) were demonstrated in liquid and solid states. For the liquid state, the absorption and fluorescence spectra of the LD-473 in Methyl Methacrylate showed bands at 385 and 420 nm, respectively. LD-473 in the solid state showed one absorption band at 530 nm, while the...

Abstract Introduction Correct femoral tunnel position in anterior cruciate ligament reconstruction (ACLR) is critical obtaining good clinical outcomes. We aimed to delineate whether any difference exists between the anteromedial and trans-tibial portal placement techniques on primary outcome of ACLR, graft rupture. Method Adult patients (>18 years old) who underwent ACLR January 2011 - 2...

In contrast to earlier studies (Bothwell et al. 1993, 1994; DeNicola and Hoagland 1996; Kiffney et al. 1997b), Hill et al. (1997) recently concluded that there was no effect of ambient solar ultraviolet (UV) radiation on periphyton and grazers in a small Tennessee stream. These conclusions were based on the appearance that grazing pressure by pleurocerid snails (Elimia clavaeformis) controlled ...

Constant-infusion experiments were performed in 14 dogs to determine the penetration into bone of rifampin and a new C-3 substituted rifamycin, DL 473. The drugs were assayed in cortical bone and medulla from tibia-femur and cortical and cancellous bone from rib. After identical dosage, the concentrations of DL 473 appeared to be higher, except in the medulla, although the serum concentrations ...

The bovine lactoferrin molecule and relatively long lactoferrin fragments containing residues 473 to 538 strongly inhibited adherence of Streptococcus mutans to saliva-coated hydroxyapatite beads. Each cysteine residue in Lf411 (residues 473 to 538) was replaced by a serine residue, and the mutants Lf411-C481S and Lf411-C532S strongly inhibited S. mutans adherence. These results suggest that th...

Most cancer lethality is caused by metastasis. To gain insight into the molecular basis of tumor progression to metastasis, we used the 21T series of human mammary epithelial cells obtained by successive biopsies from one breast cancer patient. The c-erbB2 gene is amplified and overexpressed in each of three 21T tumor lines. The erbB receptor tyrosine kinase-activated phosphatidylinositol 3-kin...

The pro-survival kinase Akt requires phosphorylation at two conserved residues, the activation loop site (Thr-308) and the hydrophobic motif site (Ser-473), for maximal activation. Previous reports indicate that mTORC2 is necessary for phosphorylation of the hydrophobic motif and that this site is not phosphorylated in cells lacking components of the mTORC2 complex, such as Sin1. Here we show t...

Rogelio Hasimoto-Beltrán and Ashfaq A. Khokhar 1 Centro de Investigación en Matemáticas – CIMAT Jalisco s/n, Col. Mineral de Valenciana, Guanajuato, Gto., México 36240 Tel: +52-(473)-732-7155 ext. 49636, Fax: +52-(473)-732-5749 [email protected] 2 University of Illinois at Chicago, Departments of Computer Sciences and Electrical and Computer Engineering, 851 South Morgan Street, Chicago, IL 606...