To investigate the mechanisms through which p130Cas adaptor protein is linked to tumorigenesis, we generated mouse mammary tumor virus (MMTV)-p130Cas mice overexpressing p130Cas in the mammary gland. MMTVp130Cas transgenic mice are characterized by extensive mammary epithelial hyperplasia during development and pregnancy and by delayed involution at the end of lactation. These phenotypes are as...

OBJECTIVE The primary objective of this analysis was to examine the burden of diabetes among Asians and Asian subgroups in Los Angeles County, which has the largest county population of Asians in the U.S. METHOD Data were analyzed from 6cycles of the Los Angeles County Health Survey, 1997-2011 (n=47,282). Asian adults (n=4672) were categorized into the following ethnic subgroups: Chinese, Fil...

Human hybridomas have been produced by fusing peripheral blood lymphocytes from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) with the GM 4672 human cell line. 262 hybridoma clones from the fusions of four RA and five SLE patients were screened for binding to denatured DNA (dDNA), native DNA, and the Fc fragment of human IgG (HIgG). Of the 17 hybridoma antibodie...

Recently, we have shown that association with an antimicrobial peptide (AMP) can drastically alter the diffusion behavior of the constituent lipids in model membranes (Biochemistry 49, 4672-4678). In particular, we found that the diffusion time of a tracer fluorescent lipid through a confocal volume measured via fluorescence correlation spectroscopy (FCS) is distributed over a wide range of tim...

In this study we sought to determine whether dog barks could be divided into subtypes based on context. We recorded barking from 10 adult dogs, Canis familiaris, of six breeds in three different test situations: (1) a disturbance situation in which a stranger rang the doorbell, (2) an isolation situation in which the dog was locked outside or in a room isolated from its owner and (3) a play sit...

OBJECTIVES To provide the first systematic analysis of a national (Wales) sample of free-text comments from patients with cancer, to determine emerging themes and insights regarding experiences of cancer care in Wales. DESIGN Thematic analysis of free-text data from a population-based survey. SETTING AND PARTICIPANTS Adult patients with a confirmed cancer diagnosis treated within a 3-month ...

[6] G. Jaousen, A. Meyer, J. Am. chem. SOC. l975,97,4667-4672. [7] 31P NMR (109 MHz, [DJDMSO, H,PO,): theinitial species: 6 = 32.0-34.0, 27.5-29.5, 27.3 (s); after addition of iPr,NH (0.4equiv based on Pd): 6 = 27.5-29.5, 27.8 (s), 27.3 ( s ) . [8] For this experiment 4-A MS powder was dried at 300 "C for 8 h under vacuum (< 0.05 Torr) to prevent contamination by water; otherwise, a lower deute...

BACKGROUND According to the hygiene hypothesis, infections in early life protect from allergic diseases. However, in earlier studies surrogate measures of infection rather than clinical infections were associated with decreased frequencies of atopic diseases. Exposure to infection indicating sub-clinical infection rather than clinical infection might protect from atopic diseases. OBJECTIVE to...

BACKGROUND Community-based lid surgery for trachomatous trichiasis (TT) is provided in 8 local government areas (LGAs) of Sokoto state since 2003 as part of a trachoma control programme. This study aims to assess the impact of community-based lid surgery on the magnitude of TT in 3 LGAs of Sokoto state. MATERIALS AND METHODS A population-based survey was conducted in persons aged 15 years and...

Abstract Academic misconduct is a threat to the validity and reliability of online examinations, media reports suggest that spiked dramatically in higher education during emergency shift exams caused by COVID-19 pandemic. This study reviewed survey research determine how common it for university students admit cheating exams, why they do it. We also assessed whether these self-reports increased...