We present quasi-simultaneous ASCA and RXTE observations of the most luminous known AGN in the local (z < 0.3) universe, the recently discovered quasar PDS 456. Multiwavelength observations have been conducted which show that PDS 456 has a bolometric luminosity of ∼ 10 erg s peaking in the UV part of the spectrum. In the X-ray band the 2-10 keV (rest-frame) luminosity is 10 erg s. The broad-ban...

We present evidence from BeppoSAX and XMM-Newton of extreme X-ray variability in the high luminosity radio-quiet quasar PDS 456, the most luminous known AGN at z < 0.3. Repeated X-ray flaring is found in PDS 456, over the duration of the 340 ksec long BeppoSAX observation. The X-ray flux doubles in just 30 ksec, whilst the total energy output of the flaring events is as high as 10 51 erg. Under...

We report on XMM-Newton spectroscopic observations of the luminous, radio-quiet quasar PDS 456. The hard X-ray spectrum of PDS 456 shows a deep absorption trough (constituting 50% of the continuum) at energies above 7 keV in the quasar rest frame, which can be attributed to a series of blue-shifted K-shell absorption edges due to highly ionized iron. The higher resolution soft X-ray RGS spectru...

OBJECTIVE Children admitted to hospital commonly require peripheral intravenous catheters (PIVCs) for treatment. This study sought to address a gap in the literature about current practice in the securement and dressing of PIVCs in paediatric acute care, and to ascertain the duration and failure of these devices. METHODS A prospective cohort study conducted at the Royal Children's Hospital in...

Malignant gliomas will affect 15,000-17,000 Americans each year and carry a dismal prognosis. Adjuvant chemotherapy is hampered by inadequate drug delivery, systemic toxicity, and a markedly variable biological sensitivity. Intraarterial (i.a.) therapy may enhance selectivity by improving tumor drug delivery and reducing systemic toxicity. Using melphalan given i.a., we studied the therapy of i...

We present infrared photometry and optical and infrared spectroscopy of the recentlydiscovered, extremely luminous nearby quasar PDS 456. A number of broad emission features are seen in the near-infrared which we are unable to identify. We measure a more accurate redshift from a narrow forbidden emission line and compare the optical–infrared spectrum to that of 3C 273. The close similarity sugg...

10.1 GENERAL PRINCIPLES OF EXPERIMENTAL DESIGN .............................. 424 10.1.1 Randomization ................................................................................... 430 10.1.2 Replication and Pseudoreplication ................................................. 431 10.1.3 Design Control .................................................................................. 437 10...

Atherosclerosis: Defeat of the Defense? Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 2001 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation Research doi: 10.1161/01.RES.88.5.456 2001;88:456-457 Circ Res. http://circres.ahajournals.org/content/88/5/456 World Wide Web at: The onli...

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