Triple negative breast cancer (TNBC) progresses rapidly but lacks effective targeted therapies. Our previous study showed that downregulating syndecan-binding protein (SDCBP) in TNBC inhibits the proliferation of TNBC cells. Dasatinib is a new small-molecule inhibitor of c-src phosphorylation. The aim of this study was to investigate if SDCBP is a potential marker to indicate whether a TNBC is ...

background: ß-carbolines, harmaline and harmine, are the major alkaloids presenting in the seeds of the peganum harmala l. these alkaloids are known as herbal active principals with potential use in pharmaceutical and medicine. objectives: to assess the growth inhibitory effect of phyto-alkaloids, harmaline and harmine, on cancer cell lines. methods: the p. harmala l.’s alkaloids were extracted...

Objective(s) Curative treatment of breast cancer patients using chemotherapy often fails as a result of intrinsic or acquired resistance of the tumor to the drug. ERK is one of the main components of the Ras/Raf/MEK/ERK cascade, which mediates signal from cell surface receptors to transcription factors to regulate different gene expression. In this study, cytotoxicity and the expression of Erk...

Background: ß-carbolines, harmaline and harmine, are the major alkaloids presenting in the seeds of the Peganum harmala L. These alkaloids are known as herbal active principals with potential use in pharmaceutical and medicine. Objectives: To assess the growth inhibitory effect of phyto-alkaloids, harmaline and harmine, on cancer cell lines. Method...

Bacteriology 226 Group B Streptococci 228 Group A Streptococci 229 Streptococcus pneumoniae 231 Other Streptococci 231 Enterococcus species 232 Staphylococcus aureus and Coagulase-Negative Staphylococci 232 Listeria monocytogenes 233 Escherichia coli 233 Klebsiella Species 233 Enterobacter Species 234 Citrobacter Species 234 Serratia marcescens 235 Pseudomonas aeruginosa 235 Salmonella Species ...

in order to study the mode of genetic control and heritability of morphological characteristics important for the improvement of root weight, sugar yield and white sugar yield in tropical beet, griffing's diallel cross method along with the biplot display of diallel data were applied. nine sugar beet lines including 7112-36, 7173, 474, 452, 261, 436-104, sb-firoz, rr607 and 436 were crosse...

objective(s) curative treatment of breast cancer patients using chemotherapy often fails as a result of intrinsic or acquired resistance of the tumor to the drug. erk is one of the main components of the ras/raf/mek/erk cascade, which mediates signal from cell surface receptors to transcription factors to regulate different gene expression. in this study, cytotoxicity and the expression of erk1...