تركز هذه الدارسة على طقوس التعبد التي يؤديها الفرد العراقي القديم في عصور قديمة وبشكل خاص العصر البابلي وتجسدت الطقوس بمشاهد فنية من واقع المجتمع والتركيز النحت البارز بشكل للدراسة حالات لان يعد الأعمال الفنية النادرة ، وكذلك اعتمادهم نمط محدد وهذا يظهر واضح وايضاً الاختام يدل أًن المتعبدين يؤدون نفس التعبدية تقربهم الآلهة.

AMG 416 is a novel D-amino acid-containing peptide agonist of the calcium-sensing receptor (CaSR) that is being evaluated for the treatment of secondary hyperparathyroidism in chronic kidney disease patients receiving hemodialysis. The principal amino acid residues and their location in the CaSR that accommodate AMG 416 binding and mode of action have not previously been reported. Herein we est...

A novel peptide, AMG 416 (formerly KAI-4169, and with a United States Adopted Name: velcalcetide), has been identified that acts as an agonist of the calcium-sensing receptor (CaSR). This article summarizes the in vitro and in vivo characterization of AMG 416 activity and the potential clinical utility of this novel compound. AMG 416 activates the human CaSR in vitro, acting by a mechanism dist...

AMG 416 is a novel D-amino acid–containing peptide agonist of the calcium-sensing receptor (CaSR) that is being evaluated for the treatment of secondary hyperparathyroidism in chronic kidney disease patients receiving hemodialysis. The principal amino acid residues and their location in the CaSR that accommodate AMG 416 binding and mode of action have not previously been reported. Herein we est...

0957-4174/$ see front matter 2013 Elsevier Ltd. All rights reserved. http://dx.doi.org/10.1016/j.eswa.2013.12.027 ⇑ Corresponding author. Tel.: +91 416 2202364; fax: +91 416 2243092. E-mail addresses: [email protected] (M. Monica Subashini), sksahoo@ vit.ac.in (S.K. Sahoo). 1 Tel.: +91 416 2202467; fax: +91 416 2243092. 2 Abbreviations used: PCNN, pulse coupled neural networks; ICM, i...

Src family kinases are maintained in an assembled, inactive conformation by intramolecular interactions of their SH2 and SH3 domains. Full catalytic activity requires release of these restraints as well as phosphorylation of Tyr-416 in the activation loop. In previous structures of inactive Src kinases, Tyr-416 and flanking residues are disordered. We report here four additional c-Src structure...